ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2018
Trace elements and oxidative stress in children with type 1 diabetes mellitus.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China.Biological trace element research · 2019Trial
- Association of Vitamins and Minerals with Type 1 Diabetes Risk: A Mendelian Randomization Study.Nutrients · 2025Article
- MgJournal of cellular physiology · 2025Article
- Comparative Study of Oxidative Stress Responses in Pediatric Type 1 Diabetes and Transient Hyperglycemia.International journal of molecular sciences · 2025Article
- Dietary Antioxidant Minerals (Cr, Mg, Cu, Se, Zn) in Diabetic Children and their Relationship with Fasting and Postprandial Blood Glucose.International journal of preventive medicine · 2025Article
- Relationship between serum magnesium levels and glycemic control and insulin resistance.Northern clinics of Istanbul · 2025Article
- Evaluation of folliculogenesis and oxidative stress parameters in type 1 diabetes mellitus women with different glycemic profiles.Endocrine · 2024Article
- Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth.International journal of molecular sciences · 2024Review
- Magnesium intake and serum magnesium concentration in children with type 1 diabetes mellitus: association with glycemic control and clinical symptoms.Frontiers in nutrition · 2024Article
- The Regulation of Selenoproteins in Diabetes: A New Way to Treat Diabetes.Current pharmaceutical design · 2024Review
- The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess Body Weight.International journal of molecular sciences · 2023Observational
- Determinants Related to Oxidative Stress Parameters in Pediatric Patients with Type 1 Diabetes Mellitus.Nutrients · 2023Article
- Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes.Biological trace element research · 2023Article
- Copper/Zinc Ratio in Childhood and Adolescence: A Review.Metabolites · 2023Review
- Air Pollution, Oxidative Stress, and the Risk of Development of Type 1 Diabetes.Antioxidants (Basel, Switzerland) · 2022Review
- Review
- Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis.Biosensors · 2022Article
- Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review.Frontiers in surgery · 2022Review
- The Therapeutic Effects of Magnesium in Insulin Secretion and Insulin Resistance.Advanced biomedical research · 2022Review
- Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study.Nutrients · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic control in children with T1D.
methodsA case-control study which included 100 diabetic children and 40 healthy children age, sex, and ethnicity-matched as a control group. The diabetic children were divided into poor and good controlled patients according to glycosylated hemoglobin (A1c %). Studied children underwent history taking, clinical examination and laboratory measurement of serum Se, Zn, Mg, and Cu levels, erythrocyte reduced glutathione (GSH) and peroxidase enzyme activity (GPx).
resultsSerum Se, Zn, Mg, Cu, erythrocyte GSH, and GPx were significantly lower in the diabetic group in comparison to the control group (
conclusionChildren with T1D, especially poorly controlled cases, had low serum Se, Zn, Mg, Cu, GSH, and GPx. Low serum Se in diabetic children may affect the erythrocyte GSH-GPx system.
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Registered trials
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