Evidence map›Paper›PMID 29618829›Full record

ArticleScientific reports2018

The genetic diversity within the 1.4 kb HLA-G 5' upstream regulatory region moderately impacts on cellular microenvironment responses.

Fabrício C Dias, Bruna C Bertol, Isabelle Poras, Bruno M Souto, Celso T Mendes-Junior, Erick C Castelli, Laure Gineau, Audrey Sabbagh, Nathalie Rouas-Freiss, Edgardo D Carosella and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. International journal of molecular sciences · 2023
    Article
  3. HLA-G and Recurrent Pregnancy Loss.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Review
  6. Role of HLA-G in Viral Infections.Frontiers in immunology · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Fabrício C DiasDepartment of Medicine, Division of Clinical Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, ZIP Code 14.049-900, Brazil.
Bruna C BertolDepartment of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, ZIP Code 14.049-900, Brazil.
Isabelle PorasCommissariat à l'Energie Atomique et aux Energies Alternatives, Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, ZIP code 75010, France.
Bruno M SoutoDepartment of Medicine, Division of Clinical Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, ZIP Code 14.049-900, Brazil.
Celso T Mendes-JuniorDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, ZIP Code 14.049-900, Brazil.ORCID 0000-0002-7337-1203
Erick C CastelliSão Paulo State University (UNESP), Department of Pathology, School of Medicine, Botucatu, State of São, Paulo, ZIP Code 18.618-687, Brazil.
Laure GineauUMR 216-MERIT, Institut de Recherche pour le Développement, Faculté de Pharmacie de Paris - Université Paris Descartes, COMUE Sorbonne Paris-Cité, Paris, ZIP Code 75006, France.
Audrey SabbaghUMR 216-MERIT, Institut de Recherche pour le Développement, Faculté de Pharmacie de Paris - Université Paris Descartes, COMUE Sorbonne Paris-Cité, Paris, ZIP Code 75006, France.
Nathalie Rouas-FreissCommissariat à l'Energie Atomique et aux Energies Alternatives, Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, ZIP code 75010, France.
Edgardo D CarosellaCommissariat à l'Energie Atomique et aux Energies Alternatives, Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, ZIP code 75010, France.
Eduardo A DonadiDepartment of Medicine, Division of Clinical Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, ZIP Code 14.049-900, Brazil.
Philippe MoreauCommissariat à l'Energie Atomique et aux Energies Alternatives, Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, ZIP code 75010, France. philippe.moreau@cea.fr.
Délégation Paris 7 · FRUniversidade de São Paulo · BRDélégation Paris 5 · FRUniversidade de Ribeirão Preto · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HLA-G 5'URR extending 1.4 kb from the ATG presents a unique set of regulatory elements among HLA genes. Several variable sites have been described that coincide with or are close to these elements, thus HLA-G 5'URR polymorphism might influence the HLA-G expression level. We cloned the ten most frequent HLA-G 5'URR haplotypes to evaluate their activity on a luciferase reporter gene in HLA-G

Indexed as

Cellular MicroenvironmentHaplotypesPolymorphism, Single NucleotideRegulatory Sequences, Nucleic Acid5' Untranslated RegionsAdultChoriocarcinomaFemaleGenotypeHLA-G AntigensHumansMaleMelanomaTranscription FactorsTumor Cells, Cultured5' Untranslated RegionsHLA-G AntigensTranscription Factors

Identifiers

PMID29618829
PMCPMC5884815
OpenAlexW2805110170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.