ArticleScientific reports2018
In vivo study of non-invasive effects of non-thermal plasma in pressure ulcer treatment.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 88 citations in OpenAlex.
- Adjunctive Cold Atmospheric Plasma Therapy for Tracheostomy Wound Healing in Critically Ill Patients: A Pilot Randomised Controlled Trial.International wound journal · 2026Trial
- Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Trial
- Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing.Applied microbiology and biotechnology · 2021Trial
- Cold Atmospheric Plasma Disrupts Microbial Wound Bioburden: In Vitro, Porcine MRSA Biofilm, and Clinical Fluorescence Evidence from Bench to Bedside.Biomedicines · 2026Article
- Cold microwave plasma jets for wound healing: antimicrobial efficacy, mechanisms and changes in microbial cells.Scientific reports · 2026Article
- Plasma-treated alginate hydrogels modulate porcine leukocyte activityFrontiers in immunology · 2026Article
- Multiple radiations and its effect on biological system - a review onAnnals of medicine · 2025Review
- By any other name: searching for the right plasma nomenclature.IEEE transactions on radiation and plasma medical sciences · 2025Article
- Evaluation of cold atmospheric pressure plasma effects onIranian journal of microbiology · 2025Article
- Combining Cold Atmospheric Plasma and Environmental Nanoparticle Removal Device Reduces Neurodegenerative Markers.International journal of molecular sciences · 2024Article
- Feasibility study of plasma pyrolysis on dairy waste.Heliyon · 2024Article
- Enhanced Fat Graft Viability and Remodeling Using a Helium-based Radiofrequency Device to Prepare the Recipient Site.Aesthetic plastic surgery · 2024Article
- Harnessing Non-Thermal Plasma to Supercharge Recovery in Abdominal Surgeries: A Pilot Study.Journal of clinical medicine · 2024Article
- Fracture healing on non-union fracture model promoted by non-thermal atmospheric-pressure plasma.PloS one · 2024Article
- Innovative cold atmospheric plasma (iCAP) decreases corneal ulcer formation and bacterial loads and improves anterior chamber health in methicillin resistant Staphylococcus aureus keratitis.Experimental eye research · 2023Article
- Non-Thermal Plasma Application in Medicine-Focus on Reactive Species Involvement.International journal of molecular sciences · 2023Review
- Applications of atmospheric cold plasma in agricultural, medical, and bioprocessing industries.Applied microbiology and biotechnology · 2022Review
- Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma.Frontiers in oncology · 2022Review
- Article
- Medical gas plasma-stimulated wound healing: Evidence and mechanisms.Redox biology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to high incidence and prevalence of pressure ulcers worldwide, the purpose of this study is using of non-thermal atmospheric plasma as a novel therapy for pressure ulcers. Cold plasma was produced by applying a high-voltage (5 kV) and high-frequency (25 kHz), to helium gas. Under general anesthesia and sterile conditions, two circular magnets were used to create pressure ulcers on the dorsal skin of adult rats. The wounds were divided randomly into control and plasma-treated groups. Animals in the plasma-treated group received plasma radiation for 5 days, each day 3 times and every time 60 s. Mechanical assays were performed to determine plasma effects on the mechanical strength of the repaired tissue. The results showed that mechanical strength of repaired wound in the plasma-treated group was significantly higher than that in the control group (p < 0.05). In addition, evidence from histological studies indicates a significantly accelerated wound re-epithelialization in comparison with the control group; angiogenesis and fibrosis (collagen synthesis) were also significantly increased and the inflammation phase of wound healing was shorter in the plasma-treated group. The plasma treatment also resulted in significant wound contraction and acceleration of wound healing. The findings of present study indicate the effects of cold plasma on pressure ulcer treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.