ArticleScientific reports2018
Arteriovenous blood metabolomics: An efficient method to determine the key metabolic pathway for milk synthesis in the intra-mammary gland.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Graded selenium supplementation restructures yak colostrum composition and metabolomic organization under high-altitude conditions.Food chemistry: X · 2026Article
- Rumen-Plasma-Milk Metabolomics Profiling Revealed Metabolic Alterations Associated with Milk Fat Synthesis in Chinese Holstein Cows.Animals : an open access journal from MDPI · 2026Article
- Investigation of Ginseng-Ophiopogon Injection on Enhancing Physical Function by Pharmacogenomics and Metabolomics Evaluation.Combinatorial chemistry & high throughput screening · 2024Article
- Heat stress affects dairy cow health status through blood oxygen availability.Journal of animal science and biotechnology · 2023Article
- Cerebral venous biomarkers and veno-arterial gradients: untapped resources in Alzheimer's disease.Frontiers in neurology · 2023Article
- Constraints on the utilization of cereal straw in lactating dairy cows: A review from the perspective of systems biology.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Metagenomic and Metabolomic Insights Into the Mechanism Underlying the Disparity in Milk Yield of Holstein Cows.Frontiers in microbiology · 2022Article
- Assessing metabolic properties of dairy cows fed low quality straws by integrative arterial and venous metabolomics.Asian-Australasian journal of animal sciences · 2020Article
- Arterio-venous metabolomics exploration reveals major changes across liver and intestine in the obese Yucatan minipig.Scientific reports · 2019Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to identify metabolic signature changes of the arteriovenous metabolome and the new metabolites that involved in mammary biological process during milk synthesis. GC/MS-based metabolomics profiling of arteriovenous plasma from 30 lactating dairy cows fed three diets identified a total of 144 metabolites. Phenylalanine and tyrosine, involved in aminoacyl-tRNA biosynthesis and phenylalanine metabolism, were shown higher expression in the artery than in the vein based on both GC/MS and targeted analysis for cows fed both alfalfa hay diet and rice straw diet. Mammary uptake or clearance of citric acid, stearic acid, oleic acid, fructose, β-mannosylglycerate, 4-hydroxybutyrate, and D-talose were significantly correlated with milk performance or feed intake, indicating that these metabolites might be newly identified precursors or indicators of milk synthesis. This comprehensive assessment of metabolic changes in the arteriovenous metabolome will provide a fundamental understanding of the key metabolites involved in milk synthesis and shows implications of how metabolites from arteriovenous plasma across MG are involved in biological processes or physiological functions for milk synthesis. The newly identified metabolites from the present study provide potential new targeted insights into the study of physiological process for milk synthesis in the MG.
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