Evidence map›Paper›PMID 29618737›Full record

SynthesisScientific reports2018

Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy.

Melanie D Napier, Nora Franceschini, Rahul Gondalia, James D Stewart, Raúl Méndez-Giráldez, Colleen M Sitlani, Amanda A Seyerle, Heather M Highland, Yun Li, Kirk C Wilhelmsen and 23 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 8 institutions in 1 country.

Melanie D NapierDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA. mdnapier@email.unc.edu.ORCID 0000-0001-7756-7257
Nora FranceschiniDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
Rahul GondaliaDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
James D StewartDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
Raúl Méndez-GiráldezDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-1853-9429
Colleen M SitlaniDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Amanda A SeyerleDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Heather M HighlandDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Kirk C WilhelmsenDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Song YanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Jeffrey RoachResearch Computing Center, University of North Carolina, Chapel Hill, NC, USA.
Jie YaoInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Susan R HeckbertCardiovascular Health Research Unit and the Department of Epidemiology, University of Washington, Seattle, WA, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Kari E NorthCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Alexander P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Zhu-Ming ZhangEpidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, NC, USA.
Lesley F TinkerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Duanping LiaoDepartment of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7231-9745
Henry J LinInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Jennifer A BrodyDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Nona SotoodehniaDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Elsayed Z SolimanDepartment of Epidemiology, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Christy L AveryDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA. eric_whitsel@med.unc.edu.ORCID 0000-0003-4843-3641
University of North Carolina at Chapel Hill · USUniversity of Washington · USThe Lundquist Institute · USWake Forest University · USFred Hutch Cancer Center · USKaiser Permanente Washington Health Research Institute · USPennsylvania State University · USUniversity of Minnesota · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Trans-ethnic meta-analysis of blood pressure in African and European ancestriesR21HL123677 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2014 to 2015
$242k
NCATS NIH HHS UL1 TR001881NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL123677NHLBI NIH HHS T32 HL007055NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

The genetic basis of supraventricular and ventricular ectopy (SVE, VE) remains largely uncharacterized, despite established genetic mechanisms of arrhythmogenesis. To identify novel genetic variants associated with SVE/VE in ancestrally diverse human populations, we conducted a genome-wide association study of electrocardiographically identified SVE and VE in five cohorts including approximately 43,000 participants of African, European and Hispanic/Latino ancestry. In thirteen ancestry-stratified subgroups, we tested multivariable-adjusted associations of SVE and VE with single nucleotide polymorphism (SNP) dosage. We combined subgroup-specific association estimates in inverse variance-weighted, fixed-effects and Bayesian meta-analyses. We also combined fixed-effects meta-analytic t-test statistics for SVE and VE in multi-trait SNP association analyses. No loci reached genome-wide significance in trans-ethnic meta-analyses. However, we found genome-wide significant SNPs intronic to an apoptosis-enhancing gene previously associated with QRS interval duration (FAF1; lead SNP rs7545860; effect allele frequency = 0.02; P = 2.0 × 10

Indexed as

Clinical Trials as TopicGenome-Wide Association StudyPolymorphism, Single NucleotideAgedAtrial Premature ComplexesBayes TheoremCohort StudiesElectrocardiographyFemaleGenotypeHumansMaleMiddle AgedPhenotypeTachycardia, SupraventricularVentricular Premature Complexes

Identifiers

PMID29618737
PMCPMC5884864
OpenAlexW2796379756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.