Evidence map›Paper›PMID 29618726›Full record

ArticleScientific reports2018

Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS).

Chuan Gao, Keri L Tabb, Latchezar M Dimitrov, Kent D Taylor, Nan Wang, Xiuqing Guo, Jirong Long, Jerome I Rotter, Richard M Watanabe, Joanne E Curran and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genome-Wide Association Study Identifies a FunctionalArteriosclerosis, thrombosis, and vascular biology · 2021
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Chuan GaoMolecular Genetics and Genomics Program, Winston-Salem, NC, USA.
Keri L TabbCenter for Genomics and Personalized Medicine Research, Winston-Salem, NC, USA.
Latchezar M DimitrovCenter for Genomics and Personalized Medicine Research, Winston-Salem, NC, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Nan WangDepartment of Preventive Medicine and Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jirong LongDepartment of Medicine and Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Richard M WatanabeDepartment of Preventive Medicine and Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Joanne E CurranSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Carl D LangefeldDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Donald W BowdenCenter for Genomics and Personalized Medicine Research, Winston-Salem, NC, USA.
Nicholette D PalmerCenter for Genomics and Personalized Medicine Research, Winston-Salem, NC, USA. nallred@wakehealth.edu.ORCID 0000-0002-0384-5944
The Lundquist Institute · USThe University of Texas Rio Grande Valley · USUniversity of Southern California · USWake Forest University · USVanderbilt University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
ROLE OF LIPOXYGENASES IN ATHEROGENESIS IN DIABETES MELLITUSP01HL055798 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI TAYLOR, ANGELA M · 1995 to 2016
$28.4M
Genetics of Beta Cell Failure in Mexican AmericansR01DK061628 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A, XIANG, ANNY H · 2003 to 2012
$10.0M
Genetic & Epidemiologic Predictors of Glucose Homeostasis Measures in HispanicsR01DK085175 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E, WATANABE, RICHARD M · 2010 to 2013
$6.9M
IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCER01HL060944 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 1999 to 2009
$5.5M
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African AmericansR01HG007112 · NHGRI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOWDEN, DONALD W, LANGEFELD, CARL D · 2012 to 2016
$4.8M
Construction of a Biomedical Research Facility at the U*C06RR020547 · NCRR · UNIV/TEXAS BROWNSVILLE & SOUTHMOST COLL · PI KROUSE, JOHN H · 2010 to 2010
$4.0M
Mapping Genes for Atherosclerosis and Insulin ResistanceR01HL088457 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ROTTER, JEROME I · 2007 to 2010
$3.0M
Genetic Determinants of Adiposity in African AmericansR01DK087914 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NG, MAGGIE · 2010 to 2014
$3.0M
IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCER01HL061019 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI NORRIS, JILL M · 1999 to 2009
$2.6M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCRR NIH HHS C06 RR020547NHGRI NIH HHS R01 HG007112NHLBI NIH HHS P01 HL055798NHLBI NIH HHS R01 HL060944NHLBI NIH HHS R01 HL061019NHLBI NIH HHS R01 HL088457NHLBI NIH HHS U01 HL047902NIDDK NIH HHS K99 DK081350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R00 DK081350NIDDK NIH HHS R01 DK061628NIDDK NIH HHS R01 DK085175NIDDK NIH HHS R01 DK087914NIDDK NIH HHS R21 DK097524
6 · The paper itself

Abstract

Genome-wide association studies have identified numerous variants associated with lipid levels; yet, the majority are located in non-coding regions with unclear mechanisms. In the Insulin Resistance Atherosclerosis Family Study (IRASFS), heritability estimates suggest a strong genetic basis: low-density lipoprotein (LDL, h

Indexed as

Genetic VariationAdultApolipoprotein A-VAtherosclerosisCarrier ProteinsExome SequencingFemaleGenetic LinkageGenome-Wide Association StudyHumansInsulin ResistanceLipidsLipoproteins, HDLMexican AmericansMiddle AgedPolymorphism, Single NucleotideAPOA5 protein, humanApolipoprotein A-VCarrier ProteinsFNIP2 protein, humanLipidsLipoproteins, HDLTriglycerides

Identifiers

PMID29618726
PMCPMC5884862
OpenAlexW2806910646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.