ReviewJCI insight2018
Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop.
Open access · goldAbstract readReview
In one paragraph
Review in JCI insight, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Extracellular RNAs as Messengers and Early Biomarkers in Neurodegeneration.International journal of molecular sciences · 2025Review
- Extracellular RNA as a molecular driver and therapeutic target in abdominal aortic aneurysms.Scientific reports · 2025Article
- Extracellular RNA communication: A decade of NIH common fund support illuminates exRNA biology.Journal of extracellular vesicles · 2025Review
- Choice of blood collection methods influences extracellular vesicles counts and miRNA profiling.Journal of extracellular biology · 2024Article
- Endocytosis blocks the vesicular secretion of exosome marker proteins.Science advances · 2024Article
- Exosomal microRNAs in regulation of tumor cells resistance to apoptosis.Biochemistry and biophysics reports · 2024Review
- Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study.BMC medicine · 2023Article
- A validation study for the utility of serum microRNA as a diagnostic and prognostic marker in patients with osteosarcoma.Oncology letters · 2023Article
- Article
- Extracellular Non-Coding RNAs in Cardiovascular Diseases.Pharmaceutics · 2023Review
- Exomeres and Supermeres: monolithic or diverse?Journal of extracellular biology · 2022Article
- Methods for Collection of Extracellular Vesicles and Their Content RNA as Liquid Biopsy for Lung Cancer Detection: Application of Differential Centrifugation and Annexin A5 Coated Beads.Current issues in molecular biology · 2022Article
- Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles.Stem cell research & therapy · 2021Review
- Extracellular mRNA transported to the nucleus exerts translation-independent function.Nature communications · 2021Article
- RI-SEC-seq: Comprehensive Profiling of Nonvesicular Extracellular RNAs with Different Stabilities.Bio-protocol · 2021Article
- Role of Exosomal miRNA in Bladder Cancer: A Promising Liquid Biopsy Biomarker.International journal of molecular sciences · 2021Review
- EV Translational Horizons as Viewed Across the Complex Landscape of Liquid Biopsies.Frontiers in cell and developmental biology · 2021Review
- Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome.Nucleic acids research · 2020Article
- How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger.Journal of extracellular vesicles · 2020Review
- MicroRNAs as Guardians of the Prostate: Those Who Stand before Cancer. What Do We Really Know about the Role of microRNAs in Prostate Biology?International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 20 institutions in 4 countries.
Kang LiDivision of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California, USA.
Rodosthenis S RodosthenousCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Fatah KashanchiLaboratory of Molecular Virology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, USA.
Thomas GingerasCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Stephen J GouldDepartment of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
Lillian S KuoNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Peter KurreDoernbecher Children's Hospital, Department of Pediatrics and Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon, USA.
Hakho LeeCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Joshua N LeonardDepartment of Chemical and Biological Engineering, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA.
Huiping LiuDepartments of Pharmacology and Medicine (Hematology and Oncology), Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Tania B LomboNIH, Office of the Director, Environmental Influences on Child Health Outcomes Program, Bethesda, Maryland, USA.
Stefan MommaInstitute of Neurology (Edinger Institute), Frankfurt University Medical School, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Frankfurt, Heidelberg, Germany.
John P NolanScintillon Institute, San Diego, California, USA.
Margaret J OchocinskaNational Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.
D Michiel PegtelDepartment of Pathology, Cancer Center Amsterdam, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands.
Yoel SadovskyMagee-Womens Research Institute, Department of Microbiology and Molecular Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Francisco Sánchez-MadridInstituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Kayla M ValdesNational Center for Advancing Translational Science, Bethesda, Maryland, USA.
Kasey C VickersDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alissa M WeaverDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, USA.
Yong ZengDepartment of Chemistry, University of Kansas Cancer Center, Lawrence, Kansas, USA.
Saumya DasCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Robert L RaffaiDivision of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California, USA.
T Kevin HowcroftCancer Immunology, Hematology, and Etiology Branch, Division of Cancer Biology, National Cancer Institute, Bethesda, Maryland, USA.
Massachusetts General Hospital · USJohns Hopkins University · USSan Francisco VA Medical Center · USCold Spring Harbor Laboratory · USDoernbecher Children's Hospital · USGeorge Mason University · USGoethe University Frankfurt · DEHospital Universitario de La Princesa · ESMagee-Womens Research Institute · USNational Cancer Institute · USNational Center for Advancing Translational Sciences · USNational Heart Lung and Blood Institute · USNational Institute of Allergy and Infectious Diseases · USNorthwestern University · USOffice of the Director · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityScintillon Institute · USUniversity of Kansas · USVanderbilt University · USVanderbilt University Medical Center · US
Funding
Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVIES, SEAN STEPHEN · 2014 to 2025
$24.7MExtracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine AbuseR01DA040385 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2015 to 2019
$2.3MHDL-microRNA Intercellular Communication in AtherosclerosisR01HL128996 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VICKERS, KASEY C · 2015 to 2019
$2.3MMacrophage SR-BI Regulates Autophagy, Angiogenin and tRNA-derived small RNAsR01HL127173 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LINTON, MACRAE F, VICKERS, KASEY C · 2016 to 2019
$2.1MHIV neuropathogenesis related to exosomes containing HIV non-coding RNAsR01NS099029 · NINDS · GEORGE MASON UNIVERSITY · PI KASHANCHI, FATAH · 2016 to 2020
$1.9MHyperglycemia and MicroRNA Dysregulation of Inflammation in AtherosclerosisR01HL133575 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI RAFFAI, ROBERT · 2016 to 2019
$1.5MIntegrated exosomes profiling for minimally invasive diagnosis and monitoring of cancerR33CA214333 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI GODWIN, ANDREW K., SAMUEL, GLENSON · 2017 to 2019
$1.2MIntegrated Microfluidic Exosome Profiling for Early Detection of CancerR21CA186846 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI ZENG, YONG · 2014 to 2016
$645kNCI NIH HHS R21 CA186846NCI NIH HHS R33 CA214333NHLBI NIH HHS P01 HL116263NHLBI NIH HHS R01 HL127173NHLBI NIH HHS R01 HL128996NHLBI NIH HHS R01 HL133575NIDA NIH HHS R01 DA040385NINDS NIH HHS R01 NS099029
Abstract
Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field.
Indexed as
AnimalsCell CommunicationCongresses as TopicDisease Models, AnimalExtracellular SpaceGene Expression RegulationHumansNational Institutes of Health (U.S.)RNATranslational Research, BiomedicalUnited StatesRNA
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.