Evidence map›Paper›PMID 29618636›Full record

ArticleMolecular systems biology2018

Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling.

C Gustavo Pesce, Stefan Zdraljevic, William J Peria, Alan Bush, María Victoria Repetto, Daniel Rockwell, Richard C Yu, Alejandro Colman-Lerner, Roger Brent

Open access · goldAbstract read
In one paragraph

Article in Molecular systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

C Gustavo PesceAbalone Bio, Inc., Richmond, CA, USA.
Stefan ZdraljevicDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID 0000-0003-2883-4616
William J PeriaFred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0003-4246-2572
Alan BushIFIBYNE-UBA-CONICET and Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
María Victoria RepettoIFIBYNE-UBA-CONICET and Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Daniel RockwellAbalone Bio, Inc., Richmond, CA, USA.
Richard C YuAbalone Bio, Inc., Richmond, CA, USA.
Alejandro Colman-LernerIFIBYNE-UBA-CONICET and Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0002-2557-8883
Roger BrentFred Hutchinson Cancer Research Center, Seattle, WA, USA rbrent@fhcrc.org.ORCID 0000-0001-8398-3273
Consejo Nacional de Investigaciones Científicas y Técnicas · ARTheraclone Sciences (United States) · USFred Hutch Cancer Center · USNorthwestern University · US

Funding

SIMULATION METHODS-PREDICITNG REGULATORY SYSTEM BEHAVIORP50HG002370 · NHGRI · VTT/MSI MOLECULAR SCIENCES INSTITUTE · PI BRENT, ROGER · 2002 to 2007
$21.5M
CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Systems biology of signal control in yeastR01GM086615 · NIGMS · VTT/MSI MOLECULAR SCIENCES INSTITUTE · PI BRENT, ROGER, YU, RICHARD C. · 2009 to 2012
$2.3M
Dynamics of gradient sensing in single cellsR01GM097479 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRENT, ROGER · 2011 to 2014
$2.1M
NHGRI NIH HHS P50 HG002370NIGMS NIH HHS R01 GM086615NIGMS NIH HHS R01 GM097479NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

Populations of isogenic cells often respond coherently to signals, despite differences in protein abundance and cell state. Previously, we uncovered processes in the

Indexed as

Single-Cell AnalysisAdaptor Proteins, Signal TransducingCell Cycle ProteinsMAP Kinase Signaling SystemMicrotubule ProteinsMicrotubulesMitogen-Activated Protein KinasesPheromonesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionAdaptor Proteins, Signal TransducingBIM1 protein, S cerevisiaeCell Cycle ProteinsFUS3 protein, S cerevisiaeMicrotubule ProteinsMitogen-Activated Protein KinasesPheromonesSaccharomyces cerevisiae ProteinsSTE5 protein, S cerevisiaecell‐to‐cell variabilitygenetic screenMAP kinasemicrotubulesnoise

Identifiers

PMID29618636
PMCPMC5884679
OpenAlexW2796463180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.