Evidence map›Paper›PMID 29618619›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.

Zhenqing Ye, Haidong Dong, Ying Li, Tao Ma, Haojie Huang, Hon Sing Leong, Jeanette Eckel-Passow, Jean-Pierre A Kocher, Han Liang, Liguo Wang

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Interferon Epsilon: Properties and Functions.Current molecular medicine · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Role of Defensins in Tumor Biology.International journal of molecular sciences · 2023
    Review
  12. Clinical features of patients withAmerican journal of cancer research · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zhenqing YeDivision of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, Minnesota.
Haidong DongDepartment of Immunology, College of Medicine, Mayo Clinic, Rochester, Minnesota.
Ying LiDivision of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, Minnesota.
Tao MaDivision of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, Minnesota.
Haojie HuangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Hon Sing LeongDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Jeanette Eckel-PassowDivision of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, Minnesota.
Jean-Pierre A KocherDivision of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, Minnesota.
Han LiangDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Liguo WangDivision of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, Minnesota. wangliguo78@gmail.com.
Mayo Clinic · US

Funding

Role of proinflammatory cytokine-induced AR degradation in castration-resistant prostate cancerR01CA130908 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HUANG, HAOJIE · 2010 to 2021
$3.5M
Role of FOXO1 Inactivation in Prostate TumorigenesisR01CA134514 · NCI · UNIVERSITY OF MINNESOTA · PI HUANG, HAOJIE · 2009 to 2019
$3.3M
Role of RUNX2 in prostate cancer intratumoral androgen synthesis and progressionR01CA193239 · NCI · MAYO CLINIC ROCHESTER · PI HUANG, HAOJIE · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA130908NCI NIH HHS R01 CA134514NCI NIH HHS R01 CA193239
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene FrequencyHomozygoteSequence DeletionAntineoplastic Agents, ImmunologicalComputational BiologyDatabases, GeneticDefensinsDrug Resistance, NeoplasmGenomicsHumansInterferon Type INeoplasmsPrognosisTreatment OutcomeAntineoplastic Agents, ImmunologicalDefensinsInterferon Type I

Identifiers

PMID29618619
PMCPMC6050078
OpenAlexW2796107408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.