Evidence map›Paper›PMID 29618611›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

FAM210A is a novel determinant of bone and muscle structure and strength.

Ken-Ichiro Tanaka, Yingben Xue, Loan Nguyen-Yamamoto, John A Morris, Ippei Kanazawa, Toshitsugu Sugimoto, Simon S Wing, J Brent Richards, David Goltzman

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Bone-muscle interactions.Osteoporosis and sarcopenia · 2025
    Review
  8. Article
  9. FAM210A: An emerging regulator of mitochondrial homeostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  10. Crosstalk between muscle and bone.Journal of bone and mineral metabolism · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ken-Ichiro TanakaCalcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada H4A 3J1.
Yingben XueCalcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada H4A 3J1.
Loan Nguyen-YamamotoCalcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada H4A 3J1.
John A MorrisDepartment of Medicine, McGill University, Montreal, QC, Canada H3T 1E2.
Ippei KanazawaInternal Medicine 1, Faculty of Medicine, Shimane University, 693-8501 Shimane, Japan.
Toshitsugu SugimotoInternal Medicine 1, Faculty of Medicine, Shimane University, 693-8501 Shimane, Japan.
Simon S WingCalcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada H4A 3J1.
J Brent RichardsDepartment of Medicine, McGill University, Montreal, QC, Canada H3T 1E2.
David GoltzmanCalcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada H4A 3J1; david.goltzman@mcgill.ca.
McGill University Health Centre · CAShimane University · JPJewish General Hospital · CAMcGill University · CA

Funding

CIHR
6 · The paper itself

Abstract

Osteoporosis and sarcopenia are common comorbid diseases, yet their shared mechanisms are largely unknown. We found that genetic variation near

Indexed as

AdultAnimalsBody WeightBone DensityCells, CulturedChildFemaleGene Expression ProfilingGenes, LethalGenes, ReporterHand StrengthHumansMaleMiceMice, KnockoutMitochondrial ProteinsFAM210A protein, humanFam210a protein, mouseMitochondrial ProteinsboneFAM210Amuscleosteoporosissarcopenia

Identifiers

PMID29618611
PMCPMC5910842
OpenAlexW2795421652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.