Evidence map›Paper›PMID 29618597›Full record

ArticleCirculation research2018

Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and Its Agonists.

Jian Shen, Ning Zhang, Yi-Nuo Lin, PingPing Xiang, Xian-Bao Liu, Peng-Fei Shan, Xin-Yang Hu, Wei Zhu, Yao-Liang Tang, Keith A Webster and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Effects of GHRH and its analogues on the Vascular System.Reviews in endocrine & metabolic disorders · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Matrix Vesicles as a Therapeutic Target for Vascular Calcification.Frontiers in cell and developmental biology · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Jian ShenFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
Ning ZhangFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
Yi-Nuo LinFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
PingPing XiangFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
Xian-Bao LiuFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
Peng-Fei ShanEndocrinology and Metabolism (P.-f.S.).
Xin-Yang HuFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
Wei ZhuFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
Yao-Liang TangVascular Biology Center, Georgia Regents University, Augusta (Y.-l.T.).
Keith A WebsterDepartment of Molecular and Cellular Pharmacology and the Vascular Biology Institute (K.A.W., R.C., A.V.S.).
Renzhi CaiDepartment of Molecular and Cellular Pharmacology and the Vascular Biology Institute (K.A.W., R.C., A.V.S.).
Andrew V SchallyDepartment of Molecular and Cellular Pharmacology and the Vascular Biology Institute (K.A.W., R.C., A.V.S.).
Jian'an WangFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.).
Hong YuFrom the Departments of Cardiology (J.S., N.Z., Y.-N.L., P.P.X., X.-b.L., X.-y.H., W.Z., J.W., H.Y.) yuvascular@zju.edu.cn wangjianan111@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNUniversity of Miami · USAugusta University · US

Funding

Regulated Therapeutic Angiogenesis: for Ischemic DiseaseR01HL072924 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WEBSTER, KEITH A · 2003 to 2014
$3.2M
NHLBI NIH HHS R01 HL072924
6 · The paper itself

Abstract

rationaleVascular calcification (VC) is a marker of the severity of atherosclerotic disease. Hormones play important roles in regulating calcification; estrogen and parathyroid hormones exert opposing effects, the former alleviating VC and the latter exacerbating it. To date no treatment strategies have been developed to regulate clinical VC.

objectiveThe objective of this study was to investigate the effect of growth hormone-releasing hormone (GHRH) and its agonist (GHRH-A) on the blocking of VC in a mouse model. METHODS AND

resultsYoung adult osteoprotegerin-deficient mice were given daily subcutaneous injections of GHRH-A (MR409) for 4 weeks. Significant reductions in calcification of the aortas of MR409-treated mice were paralleled by markedly lower alkaline phosphatase activity and a dramatic reduction in the expression of transcription factors, including the osteogenic marker gene

conclusionsGHRH-A controls osteogenesis in smooth muscle cells by targeting cross talk between protein kinase A and nuclear factor κB (p65) and through the suppression of reactive oxygen species production that induces the

Indexed as

Alkaline PhosphataseAnimalsAortaCore Binding Factor Alpha 1 SubunitCulture MediaCyclic AMP-Dependent Protein KinasesGrowth Hormone-Releasing HormoneHeart TransplantationHumansIsoquinolinesMiceMice, Inbred C57BLOsteogenesisOsteoprotegerinPeptide FragmentsReceptors, NeuropeptideAlkaline PhosphataseCore Binding Factor Alpha 1 SubunitCulture MediaCyclic AMP-Dependent Protein KinasesGrowth Hormone-Releasing HormoneIsoquinolinesN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide(N-acetyl-tyr1,D-arg2)fragment 1-29 amideOsteoprotegerinPeptide FragmentsReceptors, NeuropeptideReceptors, Pituitary Hormone-Regulating HormoneRNA, Small InterferingRUNX2 protein, humansomatotropin releasing hormone receptorSulfonamidesTnfrsf11b protein, mouseTranscription Factor RelAalkaline phosphatasegrowth hormone-releasing hormonemyocytes, smooth muscleosteogenesisreactive oxygen species

Identifiers

PMID29618597
PMCPMC5948169
OpenAlexW2796172768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.