Evidence map›Paper›PMID 29618513›Full record

ArticleThe Journal of biological chemistry2018

The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis.

Haoming Zhang, Adam L Yokom, Shen Cheng, Min Su, Paul F Hollenberg, Daniel R Southworth, Yoichi Osawa

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Impact of Metagenomics on Biocatalysis.Angewandte Chemie (International ed. in English) · 2024
    Review
  8. Review
  9. Tryptophan extends the life of cytochrome P450.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Roles of Ferredoxin-NADPAntioxidants (Basel, Switzerland) · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Biosynthesis of Enzymatically Oxidized Lipids.Frontiers in endocrinology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

Haoming ZhangFrom the Departments of Pharmacology and haom@umich.edu.ORCID 0000-0002-8765-4394
Adam L YokomBiological Chemistry and.
Shen ChengFrom the Departments of Pharmacology and.
Min Suthe Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109.
Paul F HollenbergFrom the Departments of Pharmacology and.
Daniel R SouthworthBiological Chemistry and.
Yoichi OsawaFrom the Departments of Pharmacology and osawa@umich.edu.
University of Michigan · US

Funding

P450 and NO Synthase Regulation by Multiprotein ComplexesR01GM077430 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OSAWA, YOICHI, ZHANG, HAOMING · 2006 to 2022
$6.5M
Defining the conformational cycle of nitric oxide synthasesR01GM110001 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOUTHWORTH, DANIEL RYLAND · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM077430NIGMS NIH HHS R01 GM110001
6 · The paper itself

Abstract

The cytochrome P450 enzyme CYP102A1 from

Indexed as

Protein MultimerizationBacillus megateriumBacterial ProteinsCatalysisCrystallography, X-RayCytochrome P-450 Enzyme SystemElectron TransportHemeModels, MolecularMolecular Dynamics SimulationNADPH-Ferrihemoprotein ReductaseOxidoreductasesProtein ConformationBacterial ProteinsCytochrome P-450 Enzyme Systemflavocytochrome P450 BM3 monoxygenasesHemeNADPH-Ferrihemoprotein ReductaseOxidoreductasescytochrome P450cytochrome P450 BM3dimerizationelectron microscopy (EM)electron transferfatty acid hydroxylaseheme domainprotein structurereductase domain

Identifiers

PMID29618513
PMCPMC5961045
OpenAlexW2796199871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.