Evidence map›Paper›PMID 29618511›Full record

ArticleThe Journal of biological chemistry2018

Structural and functional delineation of aerobactin biosynthesis in hypervirulent

Daniel C Bailey, Evan Alexander, Matthew R Rice, Eric J Drake, Lisa S Mydy, Courtney C Aldrich, Andrew M Gulick

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Functional characterization of iucC and iucD in iron acquisition and virulence of Cronobacter sakazakii.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  5. TheInternational journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Genomic and phenotypic insights into Serratia interaction with plants from an ecological perspective.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  11. Article
  12. Targeting Siderophore Biosynthesis to Thwart Microbial Growth.International journal of molecular sciences · 2025
    Review
  13. Review
  14. TheFrontiers in cellular and infection microbiology · 2025
    Article
  15. Review
  16. Review
  17. Molecular characterization and in-depth genomic analysis to unravel the pathogenic features of an environmental isolate Enterobacter sp. S-33.International microbiology : the official journal of the Spanish Society for Microbiology · 2024
    Article
  18. Virulence Factors inIndian journal of microbiology · 2024
    Review
  19. Review
  20. HypervirulentPathogens & immunity · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniel C BaileyFrom the Department of Structural Biology, The Jacobs School of Medicine & Biomedical Sciences, State University of New York, Buffalo, New York 14203.
Evan Alexanderthe Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Matthew R Ricethe Hauptman-Woodward Medical Research Institute, Buffalo, New York 14203, and.
Eric J DrakeFrom the Department of Structural Biology, The Jacobs School of Medicine & Biomedical Sciences, State University of New York, Buffalo, New York 14203.
Lisa S MydyFrom the Department of Structural Biology, The Jacobs School of Medicine & Biomedical Sciences, State University of New York, Buffalo, New York 14203.
Courtney C Aldrichthe Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Andrew M GulickFrom the Department of Structural Biology, The Jacobs School of Medicine & Biomedical Sciences, State University of New York, Buffalo, New York 14203, gulick@hwi.buffalo.edu.ORCID 0000-0003-4238-7453
Hauptman-Woodward Medical Research Institute · USUniversity of Minnesota · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
TRAINING IN MICROBIAL PATHOGENESIST32AI007614 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI READ, LAURIE K. · 1999 to 2015
$2.1M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
Development of HTP Assay for Inhibitors of Aerobactin ProductionR01AI116998 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GULICK, ANDREW M · 2016 to 2018
$1.4M
NCATS NIH HHS UL1 TR001412NIAID NIH HHS R01 AI116998NIAID NIH HHS T32 AI007614NIH HHS S10 OD012289
6 · The paper itself

Abstract

Aerobactin, a citryl-hydroxamate siderophore, is produced by a number of pathogenic Gram-negative bacteria to aid in iron assimilation. Interest in this well-known siderophore was reignited by recent investigations suggesting that it plays a key role in mediating the enhanced virulence of a hypervirulent pathotype of

Indexed as

Catalytic DomainCloning, MolecularCrystallography, X-RayEscherichia coliGene ExpressionGenetic VectorsHumansHydroxamic AcidsKineticsKlebsiella InfectionsKlebsiella pneumoniaeModels, MolecularOxo-Acid-LyasesProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-Strandaerobactinaerobactin synthetaseHydroxamic AcidsOxo-Acid-LyasesRecombinant ProteinsSiderophoresVirulence FactorsAerobactinenzyme structureKlebsiella pneumonianatural product biosynthesisprotein structuresiderophorestructural biologySurface Entropy ReductionX-ray crystallography

Identifiers

PMID29618511
PMCPMC5961048
OpenAlexW2796397937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.