ArticleSchizophrenia research2018
Telomere length and early trauma in schizophrenia.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Leukocyte telomere length in patients with schizophrenia and related disorders: a meta-analysis of case-control studies.Molecular psychiatry · 2022Pooled it
- Adverse Childhood Experiences and Telomere Length a Look Into the Heterogeneity of Findings-A Narrative Review.Frontiers in neuroscience · 2019Pooled it
- Telomere length and mitochondrial DNA copy number in association with trauma-focused psychotherapy efficacy.Neuroscience applied · 2025Article
- How physical multimorbidity affected the mental health and healthcare utilization of patients with severe mental illness during the COVID-19 pandemic and earthquakes.Frontiers in psychiatry · 2025Article
- Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition.Schizophrenia research · 2024Article
- Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1.Translational psychiatry · 2024Article
- Epigenetic clocks in relapse after a first episode of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- A scoping systematic review of social stressors and various measures of telomere length across the life course.Ageing research reviews · 2018Article
- Early Senescence and Leukocyte Telomere Shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection?Brain sciences · 2018Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundChildhood trauma is emerging as a risk factor for schizophrenia, but its mechanism with respect to etiology is unknown. One possible pathway is through leucocyte telomere length (LTL) shortening, a measure of cellular aging associated with trauma. This study examined early trauma and LTL shortening in schizophrenia and considered sex effects.
methodsThe early trauma inventory (ETI) was administered to 48 adults with DSM-5 schizophrenia and 18 comparison participants. LTL was measured using qPCR. OUTCOMES: Cases had significantly more global trauma (F=4.10, p<0.01) and traumatic events (F=11.23, p<0.001), but case and control groups had similar LTL (1.91±0.74 and 1.83±0.62: p=0.68). The association of early trauma and LTL differed by sex in cases and controls (Fisher's R: Z<0.05). Significant negative associations were shown in male cases and, conversely, in female controls. For example, physical punishment was associated LTL shortening in males' cases (r=-0.429, p<01). Only female controls showed significant telomere shortening in association with early trauma.
interpretationThis data confirms the substantial excess of early trauma among schizophrenia cases. There were significant sex-differences in the relationship of the trauma to LTL, with only male cases showing the expected shortening. There were converse sex effects in the control group. Mean LTL was notably similar in cases and controls, despite the trauma-related shortening in male cases, cigarette smoking, older age and chronic illness of the cases. Factors may lengthen LTL in some schizophrenia cases. The converse sex differences in the cases are consistent with findings defective sexual differentiation in schizophrenia, consistent with other findings in the field.
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Registered trials
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