ArticleBMC geriatrics2018
The frail older person does not exist: development of frailty profiles with latent class analysis.
Article in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- An Easy-to-Implement Clinical-Trial Frailty Index Based on Accumulation of Deficits: Validation in Zoster Vaccine Clinical Trials.Clinical interventions in aging · 2022Trial
- Evaluation of two frailty indices, with practical application in a vaccine clinical trial.Human vaccines & immunotherapeutics · 2019Trial
- Identification of Frailty Subtypes in African American Adults With and Without Type 2 Diabetes: A Latent Class Analysis From the Jackson Heart Study.Diabetes, obesity & metabolism · 2026Article
- Identification of frailty heterogeneity and its transition trajectories in patients with chronic heart failure: a latent transition analysis.Frontiers in medicine · 2026Article
- Clinical sub-phenotypes of co-occurring metabolic syndrome and pre-frailty and their associated factors in older adults: findings from Whitehall II study.Frontiers in medicine · 2026Article
- Evaluation of individual and composite CT-based markers in frailty diagnostics in older patients with cancer undergoing major abdominal surgery.BMC geriatrics · 2025Article
- Frailty in older adults patients: a prospective observational cohort study on subtype identification.European journal of medical research · 2025Observational
- Frailty in motion: Amnestic mild cognitive impairment and Alzheimer's disease cohorts display heterogeneity in multimorbidity classification and longitudinal transitions.Journal of Alzheimer's disease : JAD · 2025Article
- Review
- Multidimensional health heterogeneity of Chinese older adults and its determinants.SSM - population health · 2023Article
- Can the Frailty of Older Adults in China Change? Evidence from a Random-Intercept Latent Transition Profile Analysis.Behavioral sciences (Basel, Switzerland) · 2023Article
- Heterogeneity of vulnerability and taste changes in older cancer patients undergoing chemotherapy: a latent class analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Critical Appraisal of the Concept Frailty: Rating of Frailty in Elderly People has Weak Scientific Basis and should not be Used for Managing Individual Patients.Aging and disease · 2023Article
- Professional home care providers' conceptualisations of frailty in the context of home care: A focus group study.International journal of older people nursing · 2023Article
- Digital health technology combining wearable gait sensors and machine learning improve the accuracy in prediction of frailty.Frontiers in public health · 2023Observational
- Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?Life (Basel, Switzerland) · 2022Review
- Evaluation of frailty and neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios relationship in elderly people.Nagoya journal of medical science · 2022Article
- An age-independent hospital record-based frailty score correlates with adverse outcomes after heart surgery and increased health care costs.JTCVS open · 2021Article
- Stratification in health and survival after age 100: evidence from Danish centenarians.BMC geriatrics · 2021Article
- Profiles of Frailty among Older People Users of a Home-Based Primary Care Service in an Urban Area of Barcelona (Spain): An Observational Study and Cluster Analysis.Journal of clinical medicine · 2021Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundA fundamental issue in elderly care is targeting those older people at risk and in need of care interventions. Frailty is widely used to capture variations in health risks but there is no general consensus on the conceptualization of frailty. Indeed, there is considerable heterogeneity in the group of older people characterized as frail. This research identifies frailty profiles based on the physical, psychological, social and cognitive domains of functioning and the severity of the problems within these domains.
methodsThis research was a secondary data-analysis of older persons derived from The Older Person and Informal Caregiver Minimum Dataset. Selected respondents were 60 years and older (n = 43,704; 59.6% female). The following variables were included: self-reported health, cognitive functioning, social functioning, mental health, morbidity status, and functional limitations. Using latent class analysis, the population was divided in subpopulations that were subsequently discussed in a focus group with older people for further validation.
resultsWe distinguished six frailty profiles: relatively healthy; mild physically frail; psychologically frail; severe physically frail; medically frail and multi-frail. The relatively healthy had limited problems across all domains. In three profiles older people mostly had singular problems in either the physical or psychological domain and the severity of the problems differed. Two remaining profiles were multidimensional with a combination of problems that extended to the social and cognitive domains.
conclusionsOur research provides an empirical base for meaningful frailty profiles. The profiles showed specific patterns underlying the problems in different domains of functioning. The heterogeneous population of frail older people has differing needs and faces different health issues that should be considered to tailor care interventions. Evaluation research of these interventions should acknowledge the heterogeneity of frailty by profiling.
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