ArticleBMC cancer2018
Breast density and breast cancer-specific survival by detection mode.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The potential association between degree of mammographic spiculation and prognosis.Insights into imaging · 2026Article
- Impact of Method of Detection of Breast Cancer on Clinical Outcomes in Individuals Aged 40 Years or Older.Radiology. Imaging cancer · 2025Observational
- WHO-recommended levels of physical activity in relation to mammographic breast density, mammographic tumor appearance, and mode of detection of breast cancer.Breast cancer research : BCR · 2024Article
- Hybrid Feature Mammogram Analysis: Detecting and Localizing Microcalcifications Combining Gabor, Prewitt, GLCM Features, and Top Hat Filtering Enhanced with CNN Architecture.Diagnostics (Basel, Switzerland) · 2024Article
- The relationship between demographic factors and known risk factors with breast cancer in women aged 30-69.Annals of medicine and surgery (2012) · 2024Article
- Mammographic features and risk of breast cancer death among women with invasive screen-detected cancer in BreastScreen Norway 1996-2020.European radiology · 2024Article
- Breast density notification.Canadian family physician Medecin de famille canadien · 2024Article
- Breast Density Evaluation According to BI-RADS 5th Edition on Digital Breast Tomosynthesis: AI Automated Assessment Versus Human Visual Assessment.Journal of personalized medicine · 2023Article
- Breast Cancer Mode of Detection in a Population-Based Cohort.Mayo Clinic proceedings · 2023Article
- Convolutional neural network based on automatic segmentation of peritumoral shear-wave elastography images for predicting breast cancer.Frontiers in oncology · 2023Article
- Mammographic breast density and survival in women with invasive breast cancer.Cancer causes & control : CCC · 2022Article
- Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density.Scientific reports · 2021Article
- Breast cancer risk factors and their effects on survival: a Mendelian randomisation study.BMC medicine · 2020Article
- The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study.Acta radiologica (Stockholm, Sweden : 1987) · 2020Article
- Comparison of Mortality Among Participants of Women's Health Initiative Trials With Screening-Detected Breast Cancers vs Interval Breast Cancers.JAMA network open · 2020Article
- Executive Summary of the Early-Onset Breast Cancer Evidence Review Conference.Obstetrics and gynecology · 2020Review
- A review of the influence of mammographic density on breast cancer clinical and pathological phenotype.Breast cancer research and treatment · 2019Review
- Enhanced Monarchy Butterfly Optimization Technique for effective breast cancer diagnosis.Journal of medical systems · 2019Article
- Exploring the Role of Breast Density on Cancer Prognosis among Women Attending Population-Based Screening Programmes.Journal of oncology · 2019Article
- "Screening isn't Your Ticket to Vacation": In-depth Interviews With Women in the United States Who Experienced an Interval Breast Cancer.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast density is known to affect breast cancer risk and screening sensitivity, but it may also be associated with breast cancer survival. The interpretation of results from previous studies on breast density and survival is complicated by the association between detection mode and survival. Here, we studied the effect of breast density on breast cancer-specific survival for different detection modes (screen-detected, interval ≤ 24 or > 24 months, non-participant).
methodsData from the Nijmegen (Dutch) breast cancer screening programme were used. Women diagnosed with invasive breast cancer between 1975 and 2011 were included. Breast density was assessed visually, based on a dichotomized Wolfe scale: 'fatty breasts' (≤25%) and 'dense breasts' (> 25%). Cox proportional hazard regression was used to obtain hazard ratios (HR).
resultsWe identified 2742 eligible women, with a breast pattern available for 2233 women. A diagnosis of interval cancer (HR 2.06, 95% CI 1.62-2.61) led to a significantly increased risk of breast cancer death compared with screen-detected cancer. No significant cause-specific survival difference between women with dense and fatty breasts was observed (HR 0.94, 95% CI 0.77-1.15). The hazard was only higher for women with dense breasts among interval cancers ≤24 m (HR 1.07, 95% CI 0.74-1.56). The hazard appeared to be lower for women with dense breasts than for women with fatty breasts among screen-detected (HR 0.77, 95% CI 0.53-1.11) and interval cancers > 24 m (HR 0.80, 95% CI 0.53-1.20). None of the effects were statistically significant.
conclusionsDetection mode is strongly associated with breast cancer death. No clear association is apparent between breast density and breast cancer death, regardless of detection mode.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.