ArticleJournal of the American Chemical Society2018
Au-Catalyzed Intermolecular [2+2] Cycloadditions between Chloroalkynes and Unactivated Alkenes.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 100 citations in OpenAlex.
- Cobalt-Catalyzed Halogen-Retentive C-H Activation and Its Application in Medicinal Chemistry.JACS Au · 2026Article
- Gold(I)-Catalyzed Intermolecular Reactions of Alkynes with Carbon Nucleophiles: What We Knowand What We Don't.ACS catalysis · 2026Review
- Enantioselective cyclization of bromoenynes: mechanistic understanding of gold(i)-catalyzed alkoxycyclizations.Chemical science · 2026Article
- Approach to Heterospirocycles for Medicinal Chemistry.Organic letters · 2025Article
- Palladium-Catalyzed Site-Selective Regiodivergent Carbocyclization of Di- and Trienallenes: A Switch between Substituted Cyclohexene and Cyclobutene.Journal of the American Chemical Society · 2025Article
- The influential IPr: 25 years after its discovery.Chemical science · 2025Review
- Regiodivergent Gold-Catalyzed Rearrangement-Addition Reactions of Sulfenylated Propargylic Carboxylates with Indoles.Organic letters · 2024Article
- π-Bonding of Group 11 Metals to a Tantalum Alkylidyne Alkyl Complex Promotes Unusual Tautomerism to Bis-alkylidene and COJournal of the American Chemical Society · 2024Article
- Copper-catalyzed radical cascade reaction of simple cyclobutanes: synthesis of highly functionalized cyclobutene derivatives.Chemical science · 2022Article
- Gold(I)-Catalyzed Intermolecular Formal [4+2] Cycloaddition of O-Aryl Ynol Ethers and Enol Ethers: Synthesis of Chromene Derivatives.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- New-Generation Ligand Design for the Gold-Catalyzed Asymmetric Activation of Alkynes.ChemPlusChem · 2021Review
- Gold-Catalyzed Synthesis of Small Rings.Chemical reviews · 2021Article
- Challenges in the Highly Selective [3 + 1]-Cycloaddition of an Enoldiazoacetamide to Form a Donor-AcceptorMolecules (Basel, Switzerland) · 2021Article
- Gold(I)-Catalyzed Synthesis of 3-Sulfenyl Pyrroles and Indoles by a Regioselective Annulation of Alkynyl Thioethers.ACS catalysis · 2021Article
- Access to substituted cyclobutenes by tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition of dipropargylphosphonates under Ag/Co relay catalysis.Chemical science · 2020Article
- Cyclopropenylmethyl Cation: A Concealed Intermediate in Gold(I)-Catalyzed Reactions.Angewandte Chemie (International ed. in English) · 2020Article
- Gold(I)-Catalyzed Haloalkynylation of Aryl Alkynes: Two Pathways, One Goal.Angewandte Chemie (International ed. in English) · 2020Article
- Alkyne-Alkene [2 + 2] cycloaddition based on visible light photocatalysis.Nature communications · 2020Article
- Catalytic Enantioselective Synthesis of Cyclobutenes from Alkynes and Alkenyl Derivatives.Journal of the American Chemical Society · 2019Article
- Nickel-Catalyzed Reductive [2+2] Cycloaddition of Alkynes.Journal of the American Chemical Society · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The [2+2] cycloaddition is a versatile strategy for the synthesis of strained cyclobutenes of high synthetic value. In this study, two efficient intermolecular [2+2] cycloadditions between two different types of chloroalkynes and unactivated alkene are realized with gold catalysis. Of significance is that the reaction works with challenging monosubstituted unactivated alkenes, which is unprecedented in gold catalysis and scarcely documented in other metal-catalyzed/promoted reactions; moreover, the reaction exhibits excellent regioselectivities, which are much better than those reported in literature. With 1,2-disubstituted unactivated alkenes, the reaction is largely stereospecific. The cyclobutene products can be prepared in nearly gram scale and readily undergo further reactions including various cross-coupling reactions using the C(sp
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Registered trials
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