ArticleRheumatology (Oxford, England)2018
The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development.
Article in Rheumatology (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis.Annals of the rheumatic diseases · 2021Guideline
- Pooled it
- Hand ultrasound patterns in rheumatoid and psoriatic arthritis: the role of ultrasound in the differential diagnosis.Rheumatology international · 2020Pooled it
- Baseline synovitis-tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state.Rheumatology (Oxford, England) · 2025Trial
- The embryonic origins of site-specific arthritis.Nature immunology · 2026Article
- A matter arising: When should inflammatory and autoimmune rheumatic diseases be considered 'early'?European journal of clinical investigation · 2026Review
- Applications of musculoskeletal ultrasound in inflammatory arthritis.Clinical medicine (London, England) · 2025Review
- Article
- [Research progress of ultrasound in diagnosis and treatment of shoulder joint diseases].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- Predictive Value of Magnetic Resonance Imaging-detected Tenosynovitis of the Metacarpophalangeal and Wrist Joints for the Development of Rheumatoid Arthritis among Patients with Undifferentiated Arthritis.Internal medicine (Tokyo, Japan) · 2023Article
- The value of ultrasound-defined tenosynovitis and synovitis in the prediction of persistent arthritis.Rheumatology (Oxford, England) · 2023Article
- Bench to Bedside: Modelling Inflammatory Arthritis.Discovery immunology · 2023Review
- Predictors of interest in predictive testing for rheumatoid arthritis among first degree relatives of rheumatoid arthritis patients.Rheumatology (Oxford, England) · 2022Article
- Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study.Annals of the rheumatic diseases · 2022Article
- What Is the Value of Ultrasound in Individuals 'At-Risk' of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis?Healthcare (Basel, Switzerland) · 2021Review
- The Role of Imaging in Predicting the Development of Rheumatoid Arthritis.Rheumatology and immunology research · 2021Review
- Update on the diagnosis and management of early rheumatoid arthritis.Clinical medicine (London, England) · 2020Article
- The Role of Musculoskeletal Ultrasound in the Rheumatoid Arthritis Continuum.Current rheumatology reports · 2020Review
- Should ultrasound be used routinely in the diagnosis of rheumatoid arthritis?Irish journal of medical science · 2020Review
- Identifying 'non-progressors' among patients with arthralgia.Nature reviews. Rheumatology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesTenosynovitis (TS) is common in early arthritis. However, the value of US-defined TS in predicting RA development is unclear. We assessed the predictive utility of US-defined TS alongside US-defined synovitis and clinical and serological variables in a prospective cohort of early arthritis patients.
methodsOne hundred and seven patients with clinically apparent synovitis of one or more joint and symptom duration ⩽3 months underwent baseline clinical, laboratory and US assessment of 19 bilateral joint sites and 16 bilateral tendon compartments. Diagnostic outcome was determined after 18 months, applying the 2010 ACR/EULAR classification criteria for RA. The predictive values of US-defined TS for persistent RA were compared with those of US-defined synovitis, clinical and serological variables.
resultsA total of 4066 US joint sites and 3424 US tendon compartments were included in the analysis. Forty-six patients developed persistent RA, 17 patients developed non-RA persistent disease and 44 patients had resolving disease at follow-up. US-defined TS in at least one tendon compartment at baseline was common in all groups (RA 85%, non-RA persistent disease 71% and resolving 70%). On multi-variate analysis, US-defined digit flexor TS provided independent predictive data over and above the presence of ACPA and US-defined joint synovitis.
conclusionUS-defined digit flexor TS provided independent predictive data for persistent RA development in patients with early arthritis. The predictive utility of this tendon site should be further assessed in a larger cohort; investigators designing imaging-based predictive algorithms for RA development should include this tendon component as a candidate variable.
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