ArticlePain medicine (Malden, Mass.)2019
Systemic Exercise-Induced Hypoalgesia Following Isometric Exercise Reduces Conditioned Pain Modulation.
Article in Pain medicine (Malden, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Understanding Exercise-Induced Hypoalgesia: An Umbrella Review of Scientific Evidence and Qualitative Content Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Psychometric properties of quantitative sensory testing in healthy and patients with shoulder pain: A systematic review.Journal of musculoskeletal & neuronal interactions · 2023Pooled it
- Impact of repeated exposure to CPM on CPM efficiency and pain sensitivity in healthy adults: a randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Trial
- Hyperbaric oxygen therapy vs. pharmacological intervention in adults with fibromyalgia related to childhood sexual abuse: prospective, randomized clinical trial.Scientific reports · 2024Trial
- Exercise induced hypoalgesia during different intensities of a dynamic resistance exercise: A randomized controlled trial.PloS one · 2024Trial
- Modulation of pain perceptions following treadmill running with different intensities in females.Physiological reports · 2023Trial
- Trial
- Hypoalgesia after exercises with painful vs. non-painful muscles in healthy subjects - a randomized cross-over study.Scandinavian journal of pain · 2022Trial
- Isometric exercises do not provide immediate pain relief in Achilles tendinopathy: A quasi-randomized clinical trial.Scandinavian journal of medicine & science in sports · 2020Trial
- The immediate effects of wrist extensor training with blood flow restriction on pain perception in middle-aged patients with lateral elbow tendinopathy: A cross-over randomized controlled trial.Sports medicine and health science · 2026Article
- Does transcranial direct current stimulation enhance the hypoalgesic effect of exercise?Sports medicine and health science · 2026Article
- Opposite effects of isometric exercise on pain sensitivity of healthy individuals: the role of pain modulation.Pain reports · 2024Article
- Reliability of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) in Participants with and without Chronic Shoulder Pain.Healthcare (Basel, Switzerland) · 2024Article
- Muscle activity and hypoalgesia in blood flow restricted versus unrestricted effort-matched resistance exercise in healthy adults.Physiological reports · 2024Article
- Exercise-Induced Hypoalgesia in Patients with Chronic Whiplash-Associated Disorders: Differences between Subgroups Based on the Central Sensitization Inventory.Journal of clinical medicine · 2024Article
- Exercised-Induced Hypoalgesia following An Elbow Flexion Low-Load Resistance Exercise with Blood Flow Restriction: A Sham-Controlled Randomized Trial in Healthy Adults.Healthcare (Basel, Switzerland) · 2022Article
- [Pain modulation through exercise : Exercise-induced hypoalgesia in physiotherapy].Schmerz (Berlin, Germany) · 2022Review
- Effects of Percutaneous Electrolysis on Endogenous Pain Modulation: A Randomized Controlled Trial Study Protocol.Brain sciences · 2021Article
- Exercise-induced pain threshold modulation in healthy subjects: a systematic review and meta-analysis.Principles and practice of clinical research (2015) · 2020Article
- Fatiguing Trunk Flexor Exercise Decreases Pain Sensitivity in Postpartum Women.Frontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Objective: Physically active individuals show greater conditioned pain modulation (CPM) compared with less active individuals. Understanding the effects of acute exercise on CPM may allow for a more targeted use of exercise in the management of pain. This study investigated the effects of acute isometric exercise on CPM. In addition, the between-session and within-session reliability of CPM was investigated. Design: Experimental, randomized crossover study. Setting: Laboratory at Marquette University. Subjects: Thirty healthy adults (19.3±1.5 years, 15 males). Methods: Subjects underwent CPM testing before and after isometric exercise (knee extension, 30% maximum voluntary contraction for three minutes) and quiet rest in two separate experimental sessions. Pressure pain thresholds (PPTs) at the quadriceps and upper trapezius muscles were assessed before, during, and after ice water immersions. Results: PPTs increased during ice water immersion (i.e., CPM), and quadriceps PPT increased after exercise (P < 0.05). CPM decreased similarly following exercise and quiet rest (P > 0.05). CPM within-session reliability was fair to good (intraclass correlation coefficient [ICC] = 0.43-0.70), and the between-session reliability was poor (ICC = 0.20-0.35). Due to the variability in the systemic exercise-induced hypoalgesia (EIH) response, participants were divided into systemic EIH responders (N = 9) and nonresponders (N = 21). EIH responders experienced attenuated CPM following exercise (P = 0.03), whereas the nonresponders showed no significant change (P > 0.05). Conclusions: Isometric exercise decreased CPM in individuals who reported systemic EIH, suggesting activation of shared mechanisms between CPM and systemic EIH responses. These results may improve the understanding of increased pain after exercise in patients with chronic pain and potentially attenuated CPM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.