ArticleSocial cognitive and affective neuroscience2018
Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?
Article in Social cognitive and affective neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Individual Differences in Heartbeat-Tone Synchronicity Judgments Suggest the Two-Alternative Heartbeat Detection Task Is a Poor Test of Cardiac Interoceptive Accuracy and Insight.Psychophysiology · 2026Article
- Oxytocin-induced modulation of explicit and implicit visual perspective taking.Scientific reports · 2026Article
- Oxytocin and cardiometabolic interoception: Knowing oneself affects ingestive and social behaviors.Appetite · 2022Article
- FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.Neuroscience and biobehavioral reviews · 2022Review
- Alcohol use and interoception - A narrative review.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Cardiovascular mechanisms of interoceptive awareness: Effects of resonance breathing.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021Article
- Alcohol and oxytocin: Scrutinizing the relationship.Neuroscience and biobehavioral reviews · 2021Review
- Evidence toward the potential absence of relationship between temporal and spatial heartbeats perception.Scientific reports · 2021Article
- The perspectives of mapping and monitoring of the sense of self in neurosurgical patients.Acta neurochirurgica · 2021Review
- The Effectiveness of Intranasal Oxytocin on Addiction Severity Index and Anhedonia Symptoms in an Alcoholic Case with Oropharyngeal Cancer, a Protocol for a Single-case Experimental Design Pilot Study.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Signatures of alcohol use in the structure and neurochemistry of insular cortex: a correlational study.Psychopharmacology · 2019Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interoception, i.e. the perception and appraisal of internal bodily signals, is related to the phenomenon of craving, and is reportedly disrupted in alcohol use disorders. The hormone oxytocin influences afferent transmission of bodily signals and, through its potential modulation of craving, is proposed as a possible treatment for alcohol use disorders. However, oxytocin's impact on interoception in alcohol users remains unknown. Healthy alcohol users (n = 32) attended two laboratory sessions to perform tests of interoceptive ability (heartbeat tracking: attending to internal signals and, heartbeat discrimination: integrating internal and external signals) after intranasal administration of oxytocin or placebo. Effects of interoceptive accuracy, oxytocin administration and alcohol intake, were tested using mixed-effects models. On the tracking task, oxytocin reduced interoceptive accuracy, but did not interact with alcohol consumption. On the discrimination task, we found an interaction between oxytocin administration and alcohol intake: Oxytocin, compared with placebo, increased interoceptive accuracy in heavy drinkers, but not in light social drinkers. Our study does not suggest a pure interoceptive impairment in alcohol users but instead potentially highlights reduced flexibility of internal and external attentional resource allocation. Importantly, this impairment seems to be mitigated by oxytocin. This attentional hypothesis needs to be explicitly tested in future research.
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