Observational studyInternational journal of epidemiology2019
Analysis of 'sensitive' periods of fetal and child growth.
Observational study in International journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Associations between life-course household wealth mobility and adolescent physical growth, cognitive development and emotional and behavioral problems: A birth cohort in rural western China.Frontiers in public health · 2023Trial
- Growth During Infancy and Early Childhood and Its Association With Metabolic Risk Biomarkers at 11.5 Years of Age.American journal of epidemiology · 2020Trial
- Maternal metabolic determinants of accelerated infant weight gain in early life: assessing the combined effects of gestational diabetes and pre-pregnancy overweight.BMC public health · 2026Article
- Muscle strength and power in young volleyball players: reference values and age group differences.BMC sports science, medicine & rehabilitation · 2026Article
- Childhood Growth and Later Outcomes-How We Quantify and Model Growth Matters.Paediatric and perinatal epidemiology · 2025Article
- Associations of fetal and postnatal growth trajectories with child cognition: the GUSTO cohort study.International journal of epidemiology · 2024Article
- Smaller subcortical volume relates to greater weight gain in girls with initially healthy weight.Obesity (Silver Spring, Md.) · 2024Article
- Determinants of Anishinabeck infant and early childhood growth trajectories in Northwestern Ontario, Canada: a cohort study.BMC pediatrics · 2023Article
- Growth Velocities Across Distinct Early Life Windows and Child Cognition: Insights from a Contemporary US Cohort.The Journal of pediatrics · 2023Article
- Longitudinal assessment of brain structure and behaviour in youth with rapid weight gain: Potential contributing causes and consequences.Pediatric obesity · 2023Article
- Associations of Neighborhood Opportunity and Social Vulnerability With Trajectories of Childhood Body Mass Index and Obesity Among US Children.JAMA network open · 2022Article
- Head circumference trajectories during the first two years of life and cognitive development, emotional, and behavior problems in adolescence: a cohort study.European journal of pediatrics · 2022Article
- Prenatal exposure to endocrine disrupting chemicals is associated with altered DNA methylation in cord blood.Epigenetics · 2022Article
- Applications of conceptual models from lifecourse epidemiology in ecology and evolutionary biology.Biology letters · 2022Review
- Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.Obesity (Silver Spring, Md.) · 2021Article
- Physical growth and neurodevelopment during the first year of life: a cohort study of the Japan Environment and Children's Study.BMC pediatrics · 2021Article
- Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones.JAMA network open · 2021Article
- Early childhood growth trajectory and later cognitive ability: evidence from a large prospective birth cohort of healthy term-born children.International journal of epidemiology · 2021Article
- Body Composition Measurements from Birth through 5 Years: Challenges, Gaps, and Existing & Emerging Technologies-A National Institutes of Health workshop.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Associations of types of green space across the life-course with blood pressure and body mass index.Environmental research · 2020Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundBirth weight and weight gain in infancy and early childhood are commonly studied as risk factors for later cardiometabolic diseases. In this study, we explore methods for quantifying weight gain during different age periods and for comparing the magnitude of the associations with later blood pressure.
methodsBased on data from a birth cohort study nested within a large cluster-randomized trial with repeated measures of weight from birth to 16 years of age, we compared the results of four analytic approaches to assess sensitive periods of growth in relation to blood pressure at age 16 years.
resultsApproaches based on z-scores of weight or weight gain velocity (both standardized for age and sex) or on regression-based conditional weight standardized residuals yielded more coherent results than an approach based on absolute weight gain velocity. Weight gain standardized by sex and age was positively associated with blood pressure at 16 years at all postnatal age periods, but the magnitude of association was larger during adolescence (11.5-16 years) than during earlier intervals (0-3 months, 3-12 months, 1-6.5 years or 6.5-11.5 years).
conclusionsStandardization of weight and weight gain by age and sex, or regression-based standardized residuals based on conditional weight, reflects relative gain and thus accounts for the rapid weight gains normally observed in early infancy and puberty. Adolescence appears to be a more sensitive period for relative weight gain effects on later blood pressure than earlier periods, even those of similar duration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.