ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018
Cumulative Burden of Depression and All-Cause Mortality in Women Living With Human Immunodeficiency Virus.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Antenatal depression and its predictors among HIV positive women in Sub-Saharan Africa; a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Global Systematic Review of Common Mental Health Disorders in Adults Living with HIV.Current HIV/AIDS reports · 2021Pooled it
- Longitudinal Associations of Cumulative Depression Burden With Cardiovascular Diseases and All-Cause Death Among Middle-Aged and Older Population: Evidence From 2 Nationwide Cohort Studies.Journal of the American Heart Association · 2026Article
- The kynurenine pathway in relation to depression and anhedonia symptom severity among women with HIV.Brain, behavior, & immunity - health · 2026Article
- EcoHIV Infection Disrupts Dopamine and Serotonin Transporter Function, Altering Release Dynamics in C57BL/6J Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- Cumulative burden of depression and domain-specific cognitive impairment over time in the women's interagency HIV study: A marginal structural model approach.Journal of affective disorders · 2026Article
- Coping strategies for depression among HIV-positive women in Gondar town health facilities, Northwest, Ethiopia: A cross-sectional study.International journal of mental health systems · 2025Article
- Process evaluation of the HIV+D intervention for integrating the management of depression in routine HIV care in Uganda.PLOS mental health · 2024Article
- A Heavy Burden: Preexisting Physical and Psychiatric Comorbidities and Differential Increases Among Male and Female Participants After Initiating Antiretroviral Therapy in the HIV Outpatient Study, 2008-2018.AIDS research and human retroviruses · 2022Article
- Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- Chronic SSRI treatment reverses HIV-1 protein-mediated synaptodendritic damage.Journal of neurovirology · 2021Article
- The Prevalence and Burden of Non-AIDS Comorbidities Among Women Living With or at Risk for Human Immunodeficiency Virus Infection in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Mini-review: Elucidating the psychological, physical, and sex-based interactions between HIV infection and stress.Neuroscience letters · 2021Review
- Under-documentation of psychiatric diagnoses among persons living with HIV in electronic medical records.AIDS care · 2021Article
- Engagement in Mental Health Care is Associated with Higher Cumulative Drug Exposure and Adherence to Antiretroviral Therapy.AIDS and behavior · 2019Article
- Pharmacologic Treatment of Psychiatric Disorders and Time With Unsuppressed HIV Viral Load in a Clinical HIV Cohort.Journal of acquired immune deficiency syndromes (1999) · 2019Observational
- The Impact of Cumulative Depression Along the HIV Care Continuum in Women Living With HIV During the Era of Universal Antiretroviral Treatment.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- The Role of Depression Screening and Treatment in Achieving the UNAIDS 90-90-90 Goals in Sub-Saharan Africa.AIDS and behavior · 2019Article
- Center for Epidemiological Studies-Depression Scale: Evaluation of a New Cutoff Score for Women Living with HIV.AIDS patient care and STDs · 2019Article
- Depression and all-cause mortality risk in HIV-infected and HIV-uninfected US veterans: a cohort study.HIV medicine · 2019Article
Corrections and comments
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Authors and funding
18 authors at 12 institutions in 1 country.
Funding
Abstract
Background: Research linking depression to mortality among people living with human immunodeficiency virus (PLWH) has largely focused on binary "always vs never" characterizations of depression. However, depression is chronic and is likely to have cumulative effects on mortality over time. Quantifying depression as a cumulative exposure may provide a better indication of the clinical benefit of enhanced depression treatment protocols delivered in HIV care settings. Methods: Women living with HIV (WLWH), naive to antiretroviral therapy, from the Women's Interagency HIV Study were followed from their first visit in or after 1998 for up to 10 semiannual visits (5 years). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. An area-under-the-curve approach was used to translate CES-D scores into a time-updated measure of cumulative days with depression (CDWD). We estimated the effect of CDWD on all-cause mortality using marginal structural Cox proportional hazards models. Results: Overall, 818 women contributed 3292 woman-years over a median of 4.8 years of follow-up, during which the median (interquartile range) CDWD was 366 (97-853). Ninety-four women died during follow-up (2.9 deaths/100 woman-years). A dose-response relationship was observed between CDWD and mortality. Each additional 365 days spent with depression increased mortality risk by 72% (hazard ratio, 1.72; 95% confidence interval, 1.34-2.20). Conclusions: In this sample of WLWH, increased CDWD elevated mortality rates in a dose-response fashion. More frequent monitoring and enhanced depression treatment protocols designed to reduce CDWD may interrupt the accumulation of mortality risk among WLWH.
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Registered trials
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