Trial reportThe international journal of neuropsychopharmacology2018
Dopamine Modulates the Efficiency of Sensory Evidence Accumulation During Perceptual Decision Making.
Trial report in The international journal of neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between persistent organic pollutants and Attention Deficit Hyperactivity Disorder phenotypes: Evidence from task-based neural activity in an observational study of a community sample of Canadian mother-child dyads.Environmental research · 2022Pooled it
- Selective enhancement of cost sensitivity by methylphenidate in adult ADHD: a randomized placebo-controlled trial.Psychological medicine · 2026Trial
- Pharmacological Enhancement of Dopamine Neurotransmission Does Not Affect Illusory Pattern Perception.eNeuro · 2024Trial
- Ropinirole, a dopamine agonist with high DNeuropharmacology · 2020Trial
- Dissecting the impact of depression on decision-making.Psychological medicine · 2020Trial
- Learning Experience Reverses Catecholaminergic Effects on Adaptive Behavior.The international journal of neuropsychopharmacology · 2020Trial
- Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts.The international journal of neuropsychopharmacology · 2018Trial
- Longitudinal analysis of decision-making deficits in binge-eating disorders using drift diffusion modeling.Appetite · 2026Article
- Individual differences in learning and decision-making: the role of COMT Val158Met polymorphism in transitive inference.Experimental brain research · 2026Article
- Prefrontal and parieto-occipital neural signatures of evidence accumulation and response to computerised Cognitive Behavioural Therapy in depression.Npj mental health research · 2025Article
- Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.Communications biology · 2025Article
- Catecholaminergic Modulation of Metacontrol Is Reflected in Aperiodic EEG Activity and Predicted by Baseline GABA+ and Glx Concentrations.Human brain mapping · 2025Article
- Diminished reactivity effect of confidence rating on perceptual decision-making in depression.Frontiers in neuroscience · 2025Article
- Pharmacological Elevation of Catecholamine Levels Improves Perceptual Decisions, But Not Metacognitive Insight.eNeuro · 2024Article
- Effects of Catecholaminergic and Transcranial Direct Current Stimulation on Response Inhibition.The international journal of neuropsychopharmacology · 2024Article
- Confidence ratings increase response thresholds in decision making.Psychonomic bulletin & review · 2024Article
- Neurophysiological avenues to better conceptualizing adaptive cognition.Communications biology · 2024Article
- Crowdsourcing with the drift diffusion model of decision making.Scientific reports · 2024Article
- Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Dopamine Increases Accuracy and Lengthens Deliberation Time in Explicit Motor Skill Learning.eNeuro · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Perceptual decision making is the process through which available sensory information is gathered and processed to guide our choices. However, the neuropsychopharmacological basis of this important cognitive function is largely elusive. Yet, theoretical considerations suggest that the dopaminergic system may play an important role. Methods: In a double-blind, randomized, placebo-controlled study design, we examined the effect of methylphenidate in 2 dosages (0.25 mg/kg and 0.5 mg/kg body weight) in separate groups of healthy young adults. We used a moving dots task in which the coherency of the direction of moving dots stimuli was manipulated in 3 levels (5%, 15%, and 35%). Drift diffusion modelling was applied to behavioral data to capture subprocesses of perceptual decision making. Results: The findings show that only the drift rate (v), reflecting the efficiency of sensory evidence accumulation, but not the decision criterion threshold (a) or the duration of nondecisional processes (Ter), is affected by methylphenidate vs placebo administration. Compared with placebo, administering 0.25 mg/kg methylphenidate increased v, but only in the 35% coherence condition. Administering 0.5 mg/kg methylphenidate did not induce modulations. Conclusions: The data suggest that dopamine selectively modulates the efficacy of evidence accumulation during perceptual decision making. This modulation depends on 2 factors: (1) the degree to which the dopaminergic system is modulated using methylphenidate (i.e., methylphenidate dosage) and (2) the signal-to-noise ratio of the visual information. Dopamine affects sensory evidence accumulation only when dopamine concentration is not shifted beyond an optimal level and the incoming information is less noisy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.