Evidence map›Paper›PMID 29617895›Full record

ArticleAmerican journal of hypertension2018

Risk Factors for Orthostatic Hypotension: Differences Between Elderly Men and Women.

Andrea S Méndez, Jesús D Melgarejo, Luis J Mena, Carlos A Chávez, Alicex C González, José Boggia, Joseph D Terwilliger, Joseph H Lee, Gladys E Maestre

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in American journal of hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  10. Sex-related differences in the clinical presentation of multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Review
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  17. Relation between blood pressure and pulse wave velocity for human arteries.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 5 countries.

Andrea S MéndezLaboratory of Neurosciences, School of Medicine and Institute for Biological Research, University of Zulia, Zulia, Venezuela.
Jesús D MelgarejoLaboratory of Neurosciences, School of Medicine and Institute for Biological Research, University of Zulia, Zulia, Venezuela.
Luis J MenaDepartament of Informatics, Universidad Politécnica de Sinaloa, Mazatlán, México.
Carlos A ChávezLaboratory of Neurosciences, School of Medicine and Institute for Biological Research, University of Zulia, Zulia, Venezuela.
Alicex C GonzálezCardiovascular Instituto (IECLUZ), University of Zulia, Zulia, Venezuela.
José BoggiaCentro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay.
Joseph D TerwilligerDepartment of Genetics and Development, Columbia University, New York, New York, USA.
Joseph H LeeG.H. Sergievsky Center, Columbia University, New York, New York, USA.
Gladys E MaestreLaboratory of Neurosciences, School of Medicine and Institute for Biological Research, University of Zulia, Zulia, Venezuela.
Universidad del Zulia · VEColumbia University · USNew York Psychoanalytic Society and Institute · USPolytechnic University of Puerto Rico · PRUniversidad de la República de Uruguay · UY

Funding

Gene-Environment Interactions in Cognition in Venezuelan FamiliesR01AG036469 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHACON, INARA, MAESTRE, GLADYS E. · 2011 to 2015
$2.7M
A longitudinal study of mid-to late-life blood pressure profiles as risk factors for Alzheimer´s disease in HispanicsR03AG054186 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAESTRE, GLADYS E., TERWILLIGER, JOSEPH DOUGLAS · 2016 to 2017
$163k
NIA NIH HHS R01 AG036469NIA NIH HHS R03 AG054186
6 · The paper itself

Abstract

backgroundOrthostatic hypotension (OH) occurs when mechanisms regulating blood pressure (BP) levels after standing-up are altered. It is unclear how prevalence and risk factors for OH are different between sexes. We aimed to investigate sex differences in prevalence and risk factors for OH elderly individuals.

methodsWe included 882 participants from Maracaibo Aging Study. OH was a sustained reduction of ≥20 mm Hg in systolic BP, ≥10 mm Hg in diastolic BP, or both, after 3 minutes of changing positions from supine to standing. Multivariable logistic regression models were used to examine the relationships among risk factors for OH in men and women considering interaction sex-term and stratified by sex.

resultsThe mean age was 66.7 ± 8.5 years, being similar by sex. Women and men 55-74 years had similar prevalence of OH+ (18.5% vs. 20.9%, respectively). After 75 years, the proportion of women with OH+ was lower than men (11% vs. 30%, respectively). Hypertension, specifically systolic BP ≥140 mm Hg, and high pulse pressure (PP) were related with OH+ accounted by interaction sex-term, while diastolic BP ≥90 mm Hg, antihypertensive treatment, body mass index (BMI), diabetes mellitus and age were not. Systolic BP ≥140 mm Hg increases the risk of OH only among women, while BMI showed an inverse association in both sexes.

conclusionsAlthough the prevalence of OH is similar in both sexes, there are different risk factors associated by sex. Systolic BP ≥140 mm Hg was associated with increased risk of OH only with women while BMI was a protective factor for OH in men and women.

Indexed as

Blood PressurePostureAgedAge DistributionBody Mass IndexCross-Sectional StudiesFemaleHumansHypotension, OrthostaticMaleMiddle AgedPrevalenceProtective FactorsRisk AssessmentRisk FactorsSex Distribution

Identifiers

PMID29617895
PMCPMC7190879
OpenAlexW2794598488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.