Evidence map›Paper›PMID 29617866›Full record

ArticleJournal of animal science2018

Serotonin induces parathyroid hormone-related protein in goat mammary gland.

W J Zang, H Li, Z F Zhang, R QuZhen, Y Z CuoMu, D K Zhang, J Luo, J J Loor, H L Zheng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

W J ZangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
H LiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Z F ZhangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
R QuZhenCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Y Z CuoMuCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
D K ZhangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
J LuoCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
J J LoorDepartment of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, IL.
H L ZhengCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Northwest A&F University · CNUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During lactation, large amounts of calcium are exported from the mammary gland into milk to ensure skeletal growth of the offspring. Recent studies revealed that serotonin (5-HT) is essential to stimulate skeletal calcium resorption for milk synthesis. Our objective was to explore the correlation between circulating 5-HT and serum calcium and parathyroid hormone-related protein (PTHrP) concentrations around parturition in dairy goats. We also investigated the effect of 5-HT on PTHrP expression in cultured primary goat mammary epithelial cells (GMEC). Blood samples of multiparous Guanzhong dairy goats were collected on day -5 to 3 postpartum for analysis of serum concentrations of calcium, 5-HT, and PTHrP. Results revealed that from day -3 to 0 postpartum serum calcium and 5-HT concentrations decreased progressively, but serum PTHrP concentration only had a sharp drop in the postpartum period sampled. Correlation analysis of circulating 5-HT and serum calcium and PTHrP concentrations on day 1 and 2 postpartum revealed that low serum 5-HT concentration was positively correlated with serum total calcium or PTHrP concentration. By knocking down tryptophan hydroxylase-1 (TPH1) or adding 5-hydroxytryptophan (5-HTP) to decrease or increase the levels of 5-HT in GMEC, we observed that 5-HTP increased PTHrP expression in a dose-dependent manner and siTPH1 decreased PTHrP protein expression. Furthermore, 5-HT increased mRNA abundance of calcium-sensing receptor (CaSR) in a dose-dependent manner and decreased the expression of plasma membrane Ca2+ ATPase-1 (PMCA1). Taken together, 5-HT seems to induce PTHrP expression in goat mammary cells during and after parturition. These findings suggest that increasing 5-HT biosynthesis could be a potential therapeutic target for prevention of hypocalcemia in dairy goats.

Indexed as

AnimalsCalciumFemaleGoatsLactationMammary Glands, AnimalMilkParathyroid Hormone-Related ProteinParturitionPostpartum PeriodPregnancyRNA, MessengerSerotoninCalciumParathyroid Hormone-Related ProteinRNA, MessengerSerotonin

Identifiers

PMID29617866
PMCPMC6093522
OpenAlexW2796156511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.