SynthesisDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2018
Natural history of eosinophilic esophagitis: a systematic review of epidemiology and disease course.
Synthesis in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 5 of them syntheses that pooled it.
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Who cites it
85 citing papers in PubMed, 5 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis.Alimentary pharmacology & therapeutics · 2025Pooled it
- BRAZILIAN GASTROENTEROLOGY FEDERATION (FBG) CLINICAL GUIDELINE: DIAGNOSIS AND TREATMENT OF EOSINOPHILIC ESOPHAGITIS IN ADULTS AND ADOLESCENTS.Arquivos de gastroenterologia · 2025Guideline
- Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta-analysis.United European gastroenterology journal · 2024Pooled it
- A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide.Annals of medicine · 2022Pooled it
- Pooled it
- Eosinophilic Oesophagitis Beyond the Oesophagus: High Prevalence of Chronic Rhinosinusitis-Type Symptoms and Their Impact on Symptom Severity in Swiss EoE Cohort Study Patients.Alimentary pharmacology & therapeutics · 2026Article
- Advancing the understanding of eosinophilic esophagitis: From pathogenesis to novel therapies.World journal of gastrointestinal pathophysiology · 2026Review
- Dysregulated IL-2 signaling and T-cell subset shifts are associated with eosinophilic esophagitis activity.Biochemistry and biophysics reports · 2026Article
- Time Trends and Impact on Treatment Outcomes of Psychiatric Diagnoses in Patients with Eosinophilic Esophagitis.Journal of gastrointestinal and liver diseases : JGLD · 2026Article
- Incidental finding of esophageal eosinophilia in patients investigated for suspected celiac disease: results from a pediatric retrospective study.European journal of pediatrics · 2026Article
- Economic burden of eosinophilic esophagitis in the first year after diagnosis in Spain: A direct medical cost analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Observational
- Eosinophilic esophagitis in Colombian children: relationship between food allergens, symptoms and endoscopic findings.BMJ paediatrics open · 2026Observational
- Histologic Response Is Associated With Improved Esophageal Distensibility and Symptom Burden in Pediatric Eosinophilic Esophagitis.Gastroenterology · 2026Article
- Overlap of Structural Gastrointestinal Disorders in Children With Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Review
- Challenges in Dietary Therapy in Pediatric Eosinophilic Esophagitis (EoE)-A Narrative Review.Nutrients · 2025Review
- Eosinophilic Esophagitis: A Review of Histopathological and Diagnostic Aspects.Diagnostics (Basel, Switzerland) · 2025Review
- Avoidant and restrictive food intake disorder among children with eosinophilic esophagitis.JPGN reports · 2025Article
- Characteristics and Clinical Management of Eosinophilic Esophagitis in Australia: A National Survey.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Research Communication: Real-World Effectiveness of Budesonide Orodispersible Tablets for Eosinophilic Oesophagitis: The Importance of Patience and Education.Alimentary pharmacology & therapeutics · 2025Article
- [Eosinophilic esophagitis-an underestimated food allergy?]Dermatologie (Heidelberg, Germany) · 2025Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophilic esophagitis is a chronic immune-mediated esophageal disorder. For its timely diagnosis, clinicians must recognize common symptoms, and understand differences in symptoms across patient groups. The aim of this study is to systematically review the epidemiology and natural history of eosinophilic esophagitis. The MEDLINE, Embase, and Cochrane databases were searched from 1974 to February 2017 for studies describing the epidemiology and natural history of eosinophilic esophagitis. Congress abstracts from 2014 to 2016 were also searched. Search results were screened against predetermined inclusion/exclusion criteria by two independent reviewers, and data extraction was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Of 1376 articles identified, 47 met the inclusion criteria: 20 on epidemiology and 27 on natural history. Incidence and prevalence of eosinophilic esophagitis varied widely across North America and Europe, and increased over time. Incidence increased 131-fold in the Netherlands (1996-2010), 20-fold in Denmark (1997-2006), and 5.1-fold in Calgary, Canada (2004-2008). The most commonly reported symptoms were emesis and abdominal pain in children, and dysphagia and food impaction in adults. Age at diagnosis was 5.9-12.0 years in children, and approximately 30 years in adults. Time between symptom onset and diagnosis was 1.2-3.5 years in children and 3.0-8.0 years in adults. Diagnostic delay was associated with an increased risk of endoscopic features of fibrostenosis. Symptoms of eosinophilic esophagitis differed significantly by age and race. In conclusion, there is an increasing incidence and prevalence of eosinophilic esophagitis. The considerable delay between symptom onset and diagnosis suggests that clinicians do not readily recognize the disease, which may have important clinical ramifications.
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Registered trials
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