ArticlePloS one2018
Emergence of Mycobacterium simiae: A retrospective study from a tertiary care center in Lebanon.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Treatment outcomes of Mycobacterium simiae pulmonary disease: a retrospective multicenter cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
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- Prevalence of Chronic Obstructive Pulmonary Disease in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Systemic Review and Meta-Analysis.Journal of personalized medicine · 2024Review
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- Absence of Tuberculosis-CausingInternational journal of microbiology · 2024Article
- Molecular epidemiology of nontuberculous mycobacteria isolated from tuberculosis-suspected patients.AMB Express · 2023Article
- Rare Mycobacteria and HIV in Children: Two Case Reports.Clinical drug investigation · 2022Article
- The Value of Sputum Polymerase Chain Reaction for Detection of Nontuberculous Mycobacteria in Cystic Fibrosis Patients with Negative Nontuberculous Mycobacteria Sputum Culture.Medical journal of the Islamic Republic of Iran · 2022Article
- Article
- Characterization of Clinical Isolates of Mycobacterium simiae Using Drug Susceptibility Tests and Molecular Analyses.Current microbiology · 2021Article
- DisseminatedBMJ case reports · 2021Article
- Article
- A case of multidrug-resistantRespirology case reports · 2021Article
- Review
- Draft Genome Sequence of Mycobacterium simiae, a Potential Pathogen Isolated from the Normal Human Oral Cavity.Microbiology resource announcements · 2020Article
- Disseminated Mycobacterium simiae infection in a patient with adult-onset immunodeficiency due to anti-interferon-gamma antibodies - a case report.BMC infectious diseases · 2020Article
- Mycobacterium simiae: Harmless colonizer or deadly pathogen?PLoS pathogens · 2020Review
- Evaluating the clinical significance of nontuberculous mycobacteria isolated from respiratory samples in Iran: an often overlooked disease.Infection and drug resistance · 2019Article
- Growing Knowledge about Mycobacterium simiae from Two Recent Studies.Antimicrobial agents and chemotherapy · 2018Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study is to describe the clinical significance of Mycobacterium simiae at a major tertiary care center in Lebanon.
methodsThis is a retrospective study of patients with positive cultures for M. simiae isolated between 2004 and 2016 at the American University of Beirut Medical Center.
resultsThis study included 103 M. simiae isolates recovered from 51 patients. Their mean age was 62.7 years. The majority were males and smokers. Specimens were mostly from respiratory sources (97%). Common comorbidities included chronic lung disease (such as chronic obstructive pulmonary disease), solid tumor, systemic disease, and diabetes mellitus. Productive cough and dyspnea were the most common symptoms. Frequent radiographic findings were infiltrates and nodules on chest X-ray and nodules, infiltrates, and bronchiectasis on chest computed tomography scan. Among 18 tested isolates, 5.8% were resistant to clarithromycin, 11.7% to amikacin, and 70-100% to other antimicrobials. Out of 13 patients receiving early treatment, 5 noted improvement, one had recurrence of symptoms, two received alternative diagnosis, and five died. Two of those deaths were related to M. simiae. Common treatment regimens included clarithromycin in different combinations with trimethoprim-sulfamethoxazole, moxifloxacin, and amikacin. Moreover, clofazimine was used in only two patients whose isolates were resistant to all but one agent. Duration of treatment ranged from 6-24 months.
conclusionIn Lebanon, M. simiae is increasingly encountered with true infection rates of at least 47%. Furthermore, the prevalence of multidrug resistance among the Lebanese M. simiae isolates is very high limiting the treatment options.
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