ArticlePLoS neglected tropical diseases2018
Refractoriness of Sergentomyia schwetzi to Leishmania spp. is mediated by the peritrophic matrix.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Sublethal Effects of the Insect Growth Regulator Novaluron on the Midgut Integrity and Survival of Adult Honey BeeACS environmental Au · 2026Article
- Identification of transporters essential for survival of Leishmania promastigotes in the digestive tract of sand flies.PLoS pathogens · 2026Article
- Application of image analysis in the evaluation of blood feeding by Lutzomyia longipalpis using an artificial feeding system with synthetic membranes.Memorias do Instituto Oswaldo Cruz · 2026Article
- Characterization of a NovelInternational journal of molecular sciences · 2025Article
- A multifaceted molecular approach to surveillance of leishmaniasis: Identification of sand fly species, Leishmania parasites, and blood meal sources using high-resolution melting analysis.PLoS neglected tropical diseases · 2025Article
- Evaluation of various membranes for blood-feeding in nine sand fly species and artificial feeding challenges in Sergentomyia minuta.Parasites & vectors · 2025Article
- Comparative Genomics Uncovers the Evolutionary Dynamics of Detoxification and Insecticide Target Genes Across 11 Phlebotomine Sand Flies.Genome biology and evolution · 2024Article
- Blood meal analysis and molecular detection of mammalian Leishmania DNA in wild-caught Sergentomyia spp. from Tunisia and Saudi Arabia.Parasitology research · 2023Article
- Investigating potential sand fly vectors after the first reported outbreak of cutaneous leishmaniasis in Ghana.Parasites & vectors · 2023Article
- Detection ofBioMed research international · 2023Article
- Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases.Transboundary and emerging diseases · 2022Review
- Experimental infections of sand flies and geckos with Leishmania (Sauroleishmania) adleri and Leishmania (S.) hoogstraali.Parasites & vectors · 2022Article
- Sand flies: Basic information on the vectors of leishmaniasis and their interactions with Leishmania parasites.Communications biology · 2022Review
- Article
- Experimental transmission of Leishmania (Mundinia) parasites by biting midges (Diptera: Ceratopogonidae).PLoS pathogens · 2021Article
- Identification of Peritrophins and Antiviral Effect ofInternational journal of molecular sciences · 2020Article
- Interactions between host biogenic amines and sand fly salivary yellow-related proteins.Parasites & vectors · 2020Article
- Association of Phlebotomus guggisbergi with Leishmania major and Leishmania tropica in a complex transmission setting for cutaneous leishmaniasis in Gilgil, Nakuru county, Kenya.PLoS neglected tropical diseases · 2019Article
- Functional genomics in sand fly-derived Leishmania promastigotes.PLoS neglected tropical diseases · 2019Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe peritrophic matrix (PM) is an acellular chitin-containing envelope which in most blood sucking insects encloses the ingested blood meal and protects the midgut epithelium. Type I PM present in sand flies and other blood sucking batch feeders is secreted around the meal by the entire midgut in response to feeding. Here we tested the hypothesis that in Sergentomyia schwetzi the PM creates a physical barrier that prevents escape of Leishmania parasites from the endoperitrophic space. METHODOLOGY/PRINCIPAL
findingsMorphology and ultrastructure of the PM as well the production of endogenous chitinase in S. schwetzi were compared with three sand fly species, which are natural vectors of Leishmania. Long persistence of the PM in S. schwetzi was not accompanied by different morphology or decreased production of chitinase. To confirm the role of the PM in refractoriness of S. schwetzi to Leishmania parasites, culture supernatant from the fungus Beauveria bassiana containing chitinase was added to the infective bloodmeal to disintegrate the PM artificially. In females treated with B. bassiana culture supernatants the PM was weakened and permeable, lacking multilayered inner structure; Leishmania colonized the midgut and the stomodeal valve and produced metacyclic forms. In control females Leishmania infections were lost during defecation. CONCLUSIONS/SIGNIFICANCE: Persistence of the PM till defecation of the bloodmeal represents an important factor responsible for refractoriness of S. schwetzi to Leishmania development. Leishmania major as well as L. donovani promastigotes survived defecation and developed late-stage infections only in females with PM disintegrated artificially by B. bassiana culture supernatants containing exogenous chitinase.
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