ArticlePLoS genetics2018
Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 50 citations in OpenAlex.
- A lipid-binding protein that boosts daytime wake is mainly located at the body surface and blocks light-induced lipid peroxidation in the brain.Current biology : CB · 2026Article
- A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026Article
- Two cytochrome P450 epoxidases mediate juvenile hormone biosynthesis in Drosophila melanogaster.Insect biochemistry and molecular biology · 2026Article
- Peripheral modulation of Pumilio in intestinal stem cells and the corpus allatum affects sleep latency in Drosophila.PloS one · 2026Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Two cytochrome P450 epoxidases mediate juvenile hormone biosynthesis inbioRxiv : the preprint server for biology · 2025Article
- Article
- The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila.PLoS biology · 2025Article
- Fly into tranquility: GABA's role in Drosophila sleep.Current opinion in insect science · 2024Review
- Reproductive hormones and sex chromosomes drive sex differences in the sleep-wake cycle.Frontiers in neuroscience · 2024Review
- Where does mating drive come from?EMBO reports · 2023Article
- Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.Development (Cambridge, England) · 2023Article
- Article
- Regulation of sleep by cholinergic neurons located outside the central brain in Drosophila.PLoS biology · 2023Article
- Article
- Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior.Current biology : CB · 2022Article
- Juvenile Hormone Studies inFrontiers in physiology · 2021Review
- Juvenile hormone affects the development and strength of circadian rhythms in young bumble beeNeurobiology of sleep and circadian rhythms · 2020Article
- The effect of the endosymbiont Wolbachia on the behavior of insect hosts.Insect science · 2020Review
- Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexually dimorphic phenotypes are a universal phenomenon in animals. In the model animal fruit fly Drosophila, males and females exhibit long- and short-sleep phenotypes, respectively. However, the mechanism is still a mystery. In this study, we showed that juvenile hormone (JH) is involved in regulation of sexually dimorphic sleep in Drosophila, in which gain of JH function enlarges differences of the dimorphic sleep phenotype with higher sleep in males and lower sleep in females, while loss of JH function blurs these differences and results in feminization of male sleep and masculinization of female sleep. Further studies indicate that germ cell-expressed (GCE), one of the JH receptors, mediates the response in the JH pathway because the sexually dimorphic sleep phenotypes cannot be rescued by JH hormone in a gce deletion mutant. The JH-GCE regulated sleep dimorphism is generated through the sex differentiation-related genes -fruitless (fru) and doublesex (dsx) in males and sex-lethal (sxl), transformer (tra) and doublesex (dsx) in females. These are the "switch" genes that separately control the sleep pattern in males and females. Moreover, analysis of sleep deprivation and circadian behaviors showed that the sexually dimorphic sleep induced by JH signals is a change of sleep drive and independent of the circadian clock. Furthermore, we found that JH seems to also play an unanticipated role in antagonism of an aging-induced sleep decrease in male flies. Taken together, these results indicate that the JH signal pathway is critical for maintenance of sexually dimorphic sleep by regulating sex-relevant genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.