Evidence map›Paper›PMID 29617063›Full record

ArticleCancer science2018

Hypocrellin B-loaded, folate-conjugated polymeric micelle for intraperitoneal targeting of ovarian cancer in vitro and in vivo.

Jie Li, Shu Yao, Kai Wang, Zaijun Lu, Xuantao Su, Li Li, Cunzhong Yuan, Jinbo Feng, Shi Yan, Beihua Kong and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jie LiDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China.
Shu YaoDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China.
Kai WangDepartment of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
Zaijun LuDepartment of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
Xuantao SuDepartment of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, China.
Li LiDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China.
Cunzhong YuanGynecology Oncology Key Laboratory, Qilu Hospital, Shandong University, Jinan, China.
Jinbo FengGynecology Oncology Key Laboratory, Qilu Hospital, Shandong University, Jinan, China.
Shi YanGynecology Oncology Key Laboratory, Qilu Hospital, Shandong University, Jinan, China.
Beihua KongDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China.
Kun SongDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China.ORCID http://orcid.org/0000-0001-6110-2770
Qilu Hospital of Shandong University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is considered an innovative and attractive modality to treat ovarian cancer. In the present study, a biodegradable polymer poly (ethylene glycol) (PEG)-poly (lactic acid)(PLA)-folate (FA-PEG-PLA) was prepared in order to synthesize an active-targeting, water-soluble and pharmacomodulated photosensitizer nanocarrier. Drug-loading content, encapsulation efficiency, in vitro and in vivo release were characterized, in which hypocrellin B (HB)/FA-PEG-PLA micelles had a high encapsulation efficiency and much slower control release for drugs compared to free drugs (P < .05). To evaluate the targeting ability of the HB/FA-PEG-PLA micelles, a cellular uptake study in vitro was carried out, which showed significantly enhanced uptake of HB/FA-PEG-PLA micelles in SKOV3 (FR+) compared to A2780 cancer cells (FR-). The enhanced uptake of HB/FA-PEG-PLA micelles to cancer cells resulted in a more effective post-PDT killing of SKOV3 cells compared to plain micelles and free drugs. Binding and uptake of HB/FA-PEG-PLA micelles by SKOV3 cells were also observed in vivo after ip injection of folate-targeted micelles in tumor-bearing ascitic ovarian cancer animals. Drug levels in ascitic tumor tissues were increased 20-fold (P < .001), which underscored the effect of a regional therapy approach with folate targeting. Furthermore, the HB-loaded micelles were mainly distributed in kidney and liver (the main clearance organs) in biodistribution. These results showed that our newly developed PDT photosensitizer HB/FA-PEG-PLA micelles have a high drug-loading capacity, good biocompatibility, controlled drug release, and enhanced targeting and antitumor effect, which is a potential approach to future targeting ovarian cancer therapy.

Indexed as

MicellesXenograft Model Antitumor AssaysAnimalsCell Line, TumorDrug CarriersDrug LiberationFemaleFolic AcidHumansMice, NudeOvarian NeoplasmsPerylenePhotosensitizing AgentsPolyestersPolyethylene GlycolsPolymersDrug CarriersFolic Acidhypocrellin BMicellesPerylenePhotosensitizing AgentsPolyesterspoly(ethylene glycol)-folatePolyethylene Glycolspoly(lactide)PolymersQuinonesfolateintraperitonealnanoparticleovarian cancertumor targeting

Identifiers

PMID29617063
PMCPMC5989858
OpenAlexW2796387580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.