ArticlePediatric research2018
Pediatric tuberculosis detection using trained African giant pouched rats.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Novel biomarkers of fetal and neonatal environmental exposure, effect and susceptibility.Pediatric research · 2025Review
- Machine Learning for Prediction of Tuberculosis Detection: Case Study of Trained African Giant Pouched Rats.Online journal of public health informatics · 2024Article
- Increased tuberculosis case detection in Tanzanian children and adults using African giant pouched rats.BMC infectious diseases · 2024Article
- Scent detection of Brucella abortus by African giant pouched rats (Cricetomys ansorgei).BMC veterinary research · 2023Article
- Pediatric Tuberculosis Diagnostics: Present and Future.Journal of the Pediatric Infectious Diseases Society · 2022Article
- Breath can discriminate tuberculosis from other lower respiratory illness in children.Scientific reports · 2021Article
- Visual Analytics of Tuberculosis Detection Rat Performance.Online journal of public health informatics · 2021Article
- Rapid TB diagnostic service and community action to FIND.TREAT.ALL#EndTB, Maputo, Mozambique, 2013-2018.Public health action · 2020Article
- The Many Hosts of Mycobacteria 8 (MHM8): A conference report.Tuberculosis (Edinburgh, Scotland) · 2020Review
- Revival of an ancient Greek art: scent detection as diagnostic tool for tuberculosis.Pediatric research · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis (TB) diagnosis in children is a challenge with up to 94% of children with TB treated empirically in TB high-burden countries. Therefore, new diagnostic tests are needed for TB diagnosis. We determined the performance of trained rats in the diagnosis of pediatric TB and whether they can improve detection rate compared to the standard of care.
methodsPresumptive TB patients in 24 TB clinics in Tanzania were tested. Samples indicated as TB-positive by rats underwent confirmation by concentrated smear microscopy. TB yield of bacteriologically confirmed pediatric TB patients (≤5 years) was compared with yield of standard of care.
resultsSputum samples from 55,148 presumptive TB patients were tested. Nine hundred eighty-two (1.8%) were the children between 1 and 5 years. Clinics detected 34 bacteriologically positive children, whereas rats detected additional 23 children yielding 57 bacteriologically TB-positive children. Rats increased pediatric TB detection by 67.6%. Among 1-14-year-old children, clinics detected 331 bacteriologically positive TB whereas rats found the additional 208 children with TB that were missed by clinics. Relative increase in TB case detection by rats decreased with the increase in age (P<0.0001).
conclusionTrained rats increase pediatric TB detection significantly and could help address the pediatric TB diagnosis challenges. Further determination of accuracy of rats involving other sample types is still needed.
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