Evidence map›Paper›PMID 29617006›Full record

ArticleCardiorenal medicine2018

Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis.

Marc M Saad, Jeanne Kamal, Elias Moussaly, Boutros Karam, Wissam Mansour, Emad Gobran, Saqib Hussen Abbasi, Ahmed Mahgoub, Puja Singh, Ross Hardy and 7 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Cardiorenal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06296160 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Role of Lung Ultrasound in the Assessment and Management of Pulmonary Congestion in Chronic Hemodialysis Patients: A Randomized Controlled Study

TypeinterventionalSponsorHamad Medical CorporationRan2023 to 2024Enrolled100ConditionsEnd Stage Renal DiseaseArmsIntervention Group
NCT07028060 nacompletednot on this mapstarted 2022, after this paper: background citation

The Detection of Lung Pathologies Among Dialysis Patients Using Novel Mobile-Phone Ultrasound - A Feasibility Pilot Study

TypeinterventionalSponsorPulseNmoreRan2022 to 2023Enrolled10ConditionsHemodialysis PatientsArmsPulseNmore MC™
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recommendations for Lung Ultrasound in Internal Medicine.Diagnostics (Basel, Switzerland) · 2020
    Guideline
  2. Article
  3. Observational
  4. Article
  5. Imaging of Congestion in Cardio-renal Syndrome.Current heart failure reports · 2025
    Review
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2022
    Review
  14. Article
  15. Observational
  16. Volume overload in hemodialysis: diagnosis, cardiovascular consequences, and management.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Review
  17. Interobserver Agreement of Lung Ultrasound Findings of COVID-19.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marc M Saad
Jeanne Kamal
Elias Moussaly
Boutros Karam
Wissam Mansour
Emad Gobran
Saqib Hussen Abbasi
Ahmed Mahgoub
Puja Singh
Ross Hardy
Devjani Das
Cara Brown
Monica Kapoor
Seleshi Demissie
Morton J Kleiner
Elie El Charabaty
Suzanne E El Sayegh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVolume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes.

methodsEnd-stage renal disease patients on HD at the Island Rehab Center being older than 18 years were screened. Patients achieving their dry weight (DW) had a lung ultrasound in a supine position. Scores were classified as mild (0-14), moderate (15-30), and severe (>30) for pulmonary congestion. Patients with more than 60 were further classified as very severe. Patients were followed for cardiac events and death.

results81 patients were recruited. 58 were males, with a mean age of 59.7 years. 44 had New York Heart Association (NYHA) class 1, 24 had class 2, and 13 had class 3. In univariate analysis, NYHA class was associated with B-line classes (<0.001) and diastolic dysfunction (0.002). In multivariate analysis, NYHA grade strongly correlated with B-line classification (0.01) but not with heart function (0.95). 71 subjects were followed for a mean duration of 1.19 years. 9 patients died and 20 had an incident cardiac event. A Kaplan-Meier survival analysis demonstrated an interval decrease in survival times in all-cause mortality and cardiac events with increased BLUS scores (p = 0.0049). Multivariate Cox regression analysis showed the independent predictive value of BLUS class for mortality and cardiac events with a heart rate of 2.98 and 7.98 in severe and very severe classes, respectively, compared to patients in the mild class (p = 0.025 and 0.013).

conclusionAt DW, BLUS is an independent risk factor for death and cardiovascular events in patients on HD.

Indexed as

Renal DialysisExtravascular Lung WaterFemaleHumansKidney Failure, ChronicLungMaleMiddle AgedPulmonary CirculationPulmonary EdemaUltrasonographyCardiovascular outcomesHemodialysisLung ultrasoundVolume overload

Identifiers

PMID29617006
PMCPMC5968278

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.