Trial reportJournal of alternative and complementary medicine (New York, N.Y.)2018
Specific Transcriptome Changes Associated with Blood Pressure Reduction in Hypertensive Patients After Relaxation Response Training.
Trial report in Journal of alternative and complementary medicine (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07653594 (TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE): A Single Arm Pilot Study
Who cites it
14 citing papers in PubMed.
- The neurobiology of love and addiction: Central nervous system signaling and energy metabolism.Cognitive, affective & behavioral neuroscience · 2025Review
- Psychological assessments, allostatic load and gene expression analyses in a randomized controlled trial comparing meditation, yoga, and stress education.Frontiers in psychology · 2025Article
- Deep rest: An integrative model of how contemplative practices combat stress and enhance the body's restorative capacity.Psychological review · 2024Article
- Mind body medicine: a modern bio-psycho-social model forty-five years after Engel.BioPsychoSocial medicine · 2023Article
- Underlying mechanisms of mindfulness meditation: Genomics, circuits, and networks.World journal of psychiatry · 2022Review
- Meditative and Mindfulness-Focused Interventions in Neurology: Principles, Science, and Patient Selection.Seminars in neurology · 2022Article
- Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Is relaxation exercise therapy effective in the management of patients with severe arterial hypertension?European journal of translational myology · 2021Article
- Mindfulness effects on lifestyle behavior and blood pressure: A randomized controlled trial.Health science reports · 2021Article
- Transcriptomics of Long-Term Meditation Practice: Evidence for Prevention or Reversal of Stress Effects Harmful to Health.Medicina (Kaunas, Lithuania) · 2021Article
- Rhythm and groove as cognitive mechanisms of dance intervention in Parkinson's disease.PloS one · 2021Article
- Psychosocial Stress and Cardiovascular Disease.Current treatment options in cardiovascular medicine · 2019Review
- Designing a Perioperative Mind-Body Intervention for Peripheral Vascular Interventions.Global advances in integrative medicine and healthArticle
- Music Therapy in Patients Undergoing Pancreatic Surgery (MUSIC PUPS): A Mixed Methods Pilot Study.Global advances in integrative medicine and healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMind-body practices that elicit the relaxation response (RR) have been demonstrated to reduce blood pressure (BP) in essential hypertension (HTN) and may be an adjunct to antihypertensive drug therapy. However, the molecular mechanisms by which the RR reduces BP remain undefined.
designGenomic determinants associated with responsiveness to an 8-week RR-based mind-body intervention for lowering HTN in 13 stage 1 hypertensive patients classified as BP responders and 11 as nonresponders were identified.
resultsTranscriptome analysis in peripheral blood mononuclear cells identified 1771 genes regulated by the RR in responders. Biological process- and pathway-based analysis of transcriptome data demonstrated enrichment in the following gene categories: immune regulatory pathways and metabolism (among downregulated genes); glucose metabolism, cardiovascular system development, and circadian rhythm (among upregulated genes). Further in silico estimation of cell abundance from the microarray data showed enrichment of the anti-inflammatory M2 subtype of macrophages in BP responders. Nuclear factor-κB, vascular endothelial growth factor, and insulin were critical molecules emerging from interactive network analysis.
conclusionsThese findings provide the first insights into the molecular mechanisms that are associated with the beneficial effects of the RR on HTN.
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Registered trials
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