Evidence map›Paper›PMID 29616463›Full record

Observational studyGeneral thoracic and cardiovascular surgery2018

The influence of comorbidity on the postoperative survival in elderly (≥ 75 years old) with lung cancer.

Tokujiro Yano, Mototsugu Shimokawa, Osamu Kawashima, Mitsuhiro Takenoyama, Yoshinori Yamashita, Takeshi Fukami, Tsuyoshi Ueno, Eiji Yatsuyanagi, Seiichi Fukuyama, National Hospital Organization Network Collaborative Research—Thoracic Oncology Group

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in General thoracic and cardiovascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tokujiro YanoDepartment of General Thoracic Surgery, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, 874-0011, Japan. tokujiro@hosp.go.jp.
Mototsugu ShimokawaCancer Biostatistics Laboratory, Clinical Research Institute, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Osamu KawashimaDepartment of Chest Surgery, National Hospital Organization Shibukawa Medical Center, Shibukawa, Japan.
Mitsuhiro TakenoyamaDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Yoshinori YamashitaDepartment of Chest Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Takeshi FukamiDepartment of Thoracic Surgery, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Tsuyoshi UenoDepartment of General Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.
Eiji YatsuyanagiDepartment of General Thoracic Surgery, National Hospital Organization Obihiro Hospital, Obihiro, Japan.
Seiichi FukuyamaDepartment of General Thoracic Surgery, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, 874-0011, Japan.
National Hospital Organization Network Collaborative Research—Thoracic Oncology Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe conducted a multi-institutional prospective observational study of elderly patients (≥ 75 years-old) with resected non-small cell lung cancer. In this report, we have followed the cohorts for 2 years after surgery and examined both the influence of preoperative comorbidity [Adult Comorbidity Evaluation-27 (ACE-27) index] on the postoperative survival and the change in the Karnofsky Performance Status (KPS).

methodsFrom March 2014 to April 2015, 264 patients were prospectively registered from 22 hospitals affiliated with the National Hospital Organization. The mean age at the time of surgery was 79.3 years (range 75-90 years), and 41% of the patients were ≥ 80 years of age. A total of 26% underwent sublobar resection. The study endpoints were the postoperative overall survival (OS), its prognostic factors, and the changes in the postoperative KPS.

resultsThe 2-year OS was 85.3% (95% confidence interval 80.4-89.1%). Male gender, age ≥ 80, a smoking history, grade 2 of ACE-27, and an advanced disease stage were significantly poor prognostic factors for the OS in the univariate risk analysis. The multivariate analysis showed that male gender, age ≥ 80, an advanced disease stage and sublobar resection were significantly poor prognostic factors for the OS. In comparison with the preoperative KPS, no marked decline was observed in the postoperative chorological change of KPS.

conclusionsIn the surgical treatment of elderly patients, the comorbidity as assessed by the ACE-27 index might affect the postoperative survival, and therefore should be taken into accounts in the preoperative evaluation of the surgical indications.

Indexed as

AgedAged, 80 and overCarcinoma, Non-Small-Cell LungComorbidityFemaleHumansJapanLung NeoplasmsMalePneumonectomyPostoperative ComplicationsPostoperative PeriodPrognosisProspective StudiesSurvival RateAdult Comorbidity Evaluation-27Karnofsky Performance StatusNon-small cell lung cancerPostoperative survivalSurgery

Identifiers

PMID29616463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.