Evidence map›Paper›PMID 29616308›Full record

ReviewSeminars in immunopathology2018

The role of extracellular vesicles when innate meets adaptive.

Tom Groot Kormelink, Sanne Mol, Esther C de Jong, Marca H M Wauben

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 80 citations in OpenAlex.

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  13. Extracellular Vesicles Released from Macrophages Infected withInternational journal of molecular sciences · 2023
    Article
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  20. Role of extracellular vesicles in severe pneumonia and sepsis.Expert opinion on biological therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tom Groot KormelinkDepartment of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. t.grootkormelink@amc.uva.nl.ORCID http://orcid.org/0000-0001-9310-5570
Sanne MolDepartment of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Esther C de JongDepartment of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Marca H M WaubenDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Amsterdam UMC Location University of Amsterdam · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate immune cells are recognized for their rapid and critical contribution to the body's first line of defense against invading pathogens and harmful agents. These actions can be further amplified by specific adaptive immune responses adapted to the activating stimulus. Recently, the awareness has grown that virtually all innate immune cells, i.e., mast cells, neutrophils, macrophages, eosinophils, basophils, and NK cells, are able to communicate with dendritic cells (DCs) and/or T and B cells, and thereby significantly contribute to the orchestration of adaptive immune responses. The means of communication that are thus far primarily associated with this function are cell-cell contacts and the release of a broad range of soluble mediators. Moreover, the possible contribution of innate immune cell-derived extracellular vesicles (EVs) to the modulation of adaptive immunity will be outlined in this review. EVs are submicron particles composed of a lipid bilayer, proteins, and nucleic acids released by cells in a regulated fashion. EVs are involved in intercellular communication between multiple cell types, including those of the immune system. A good understanding of the mechanisms by which innate immune cell-derived EVs influence adaptive immune responses, or vice versa, may reveal novel insights in the regulation of the immune system and can open up new possibilities for EVs (or their components) in controlling immune responses, either as a therapy, target, or as an adjuvant in future immune modulating treatments.

Indexed as

Adaptive ImmunityAnimalsCell CommunicationExtracellular VesiclesHumansImmunity, InnateAdaptive immunityExosomeExtracellular vesicleInnate immune cellsMicroparticleMicrovesicle

Identifiers

PMID29616308
PMCPMC6208666
OpenAlexW2796217444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.