Evidence map›Paper›PMID 29616302›Full record

ArticleJournal of neurology2018

Alterations in white matter network topology contribute to freezing of gait in Parkinson's disease.

Julie M Hall, James M Shine, Kaylena A Ehgoetz Martens, Moran Gilat, Kathryn M Broadhouse, Jennifer Y Y Szeto, Courtney C Walton, Ahmed A Moustafa, Simon J G Lewis

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Addressing the Challenges of Clinical Research for Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Brain imaging of locomotion in neurological conditions.Neurophysiologie clinique = Clinical neurophysiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julie M HallSchool of Social Sciences and Psychology, Western Sydney University, Milperra, NSW, 2214, Australia.
James M ShineBrain and Mind Centre, University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Kaylena A Ehgoetz MartensBrain and Mind Centre, University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Moran GilatBrain and Mind Centre, University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Kathryn M BroadhouseBrain and Mind Centre, University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Jennifer Y Y SzetoBrain and Mind Centre, University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Courtney C WaltonBrain and Mind Centre, University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Ahmed A MoustafaSchool of Social Sciences and Psychology, Western Sydney University, Milperra, NSW, 2214, Australia.
Simon J G LewisBrain and Mind Centre, University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia. profsimonlewis@gmail.com.

Funding

National Health and Medical Research Council of Australia program grant 1037746National Health and Medical Research Council of Australia program grant 1095127
6 · The paper itself

Abstract

Freezing of gait (FOG) is a common symptom in advanced Parkinson's disease (PD). Despite current advances, the neural mechanisms underpinning this disturbance remain poorly understood. To this end, we investigated the structural organisation of the white matter connectome in PD freezers and PD non-freezers. We hypothesized that freezers would show an altered network architecture, which could hinder the effective information processing that characterizes the disorder. Twenty-six freezers and twenty-four well-matched non-freezers were included in this study. Using diffusion tensor imaging, we investigated the modularity and integration of the regional connectome by calculating the module degree z score and the participation coefficient, respectively. Compared to non-freezers, freezers demonstrated lower participation coefficients in the right caudate, thalamus, and hippocampus, as well as within superior frontal and parietal cortical regions. Importantly, several of these nodes were found within the brain's 'rich club'. Furthermore, group differences in module degree z scores within cortical frontal and sensory processing areas were found. Together, our results suggest that changes in the structural network topology contribute to the manifestation of FOG in PD, specifically due to a lack of structural integration between key information processing hubs of the brain.

Indexed as

AgedBrainDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingGaitGait Disorders, NeurologicHumansImage Processing, Computer-AssistedMiddle AgedNeural PathwaysParkinson DiseaseWhite MatterConnectomeDiffusion imagingFreezing of gaitParkinson’s disease

Identifiers

PMID29616302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.