Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2018
Similar outcome during short-term follow-up after coated and uncoated total knee arthroplasty: a randomized controlled study.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04701359 (Comparison of Cobalt-Chromium), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Cobalt-Chromium (CoCr) Alloy and Titanium-Nitride (TiN) Coating in Total Knee Arthroplasty: A Prospective, Randomised, Double-blinded Clinical Trial
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- "Systematic review and meta-analysis of ceramic coated implants in total knee arthroplasty. Comparable mid-term results to uncoated implants."Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- No difference in patient reported outcome and inflammatory response after coated and uncoated total knee arthroplasty - a randomized controlled study.BMC musculoskeletal disorders · 2023Trial
- Increased inflammatory response is associated with less favorable functional results 5 years after total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Trial
- No clinical difference between TiN-coated versus uncoated cementless CoCrMo mobile-bearing total knee arthroplasty; 10-year follow-up of a randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Trial
- Mid-Term Results of a Cemented Titanium-Niobium Nitride-Coated Mobile Knee in Primary Total Knee Arthroplasty.Journal of clinical medicine · 2025Article
- Existing and Novel Assessment Methods for Metal Sensitivity in Elective Lower-Limb Arthroplasty-A Scoping Review.Arthroplasty today · 2024Article
- Concentrations of Cobalt, Chromium and Titanium and Immunological Changes after Primary Total Knee Arthroplasty-A Cohort Study with an 18-Year Follow-Up.Journal of clinical medicine · 2024Article
- Prosthetic Metals: Release, Metabolism and Toxicity.International journal of nanomedicine · 2024Review
- Article
- Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum.PloS one · 2023Article
- Poor Correlation Among Metal Hypersensitivity Testing Modalities and Inferior Patient-Reported Outcomes After Primary and Revision Total Knee Arthroplasties.Arthroplasty today · 2022Article
- Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants.Journal of clinical medicine · 2022Review
- Current status and future potential of wear-resistant coatings and articulating surfaces for hip and knee implants.Materials today. Bio · 2022Review
- Metal allergy in primary and revision total knee arthroplasty : a scoping review and evidence-based practical approach.Bone & joint open · 2021Article
- Metal Hypersensitivity in Joint Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2021Review
- Blood Metal Ion Release After Primary Total Knee Arthroplasty: A Prospective Study.Orthopaedic surgery · 2020Article
- Improved outcomes in patients with positive metal sensitivity following revision total knee arthroplasty.Journal of orthopaedic surgery and research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with known hypersensitivity to metals often require hypoallergenic TKA implants. Coating of a standard implant is a common solution, and although in vitro tests have demonstrated reduction of polyethylene wear for these coatings, it is still unknown whether these implants have any clinical benefit. This study was initiated to investigate metal ion concentrations, knee function and patient-reported outcome (PRO) after coated and uncoated TKA.
methodsOne hundred and twenty-two (122) patients were randomized to receive a coated or a standard TKA and, after exclusions, 59 patients were included in each group. Knee function and PRO were assessed with validated scores up to 3 years after surgery. Metal ion concentrations in blood samples were determined for chromium, cobalt, molybdenum and nickel, preoperatively and 1 year after surgery.
resultsChromium concentrations in patient plasma increased from a median of 0.25 to 1.30 µg/l in the standard TKA group, and from 0.25 to 0.75 µg/l in the coated TKA group (p = 0.012). Thirteen patients (3 coated, 10 standard TKA) had chromium concentrations above 2 µg/l. The concentrations of cobalt, molybdenum and nickel did not change. Patient-reported outcome measures (PROM) demonstrated a substantial improvement after TKA, without any differences between the groups.
conclusionThe increase in chromium concentration in the standard group needs further investigation. If surgeons use coated implants, they can be confident that these implants perform as well as standard implants. LEVEL OF EVIDENCE: I.
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Registered trials
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