ArticleFrontiers in veterinary science2018
Anesthesia-Associated Relative Hypovolemia: Mechanisms, Monitoring, and Treatment Considerations.
Article in Frontiers in veterinary science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The efficacy of ciprofol versus propofol on anesthesia in patients undergoing endoscopy: a systematic review and meta-analysis of randomized controlled trials.BMC anesthesiology · 2024Pooled it
- Terms, Definitions, Nomenclature, and Routes of Fluid Administration.Frontiers in veterinary science · 2020Pooled it
- The Impact of Individualized Hemodynamic Management on Intraoperative Fluid Balance and Hemodynamic Interventions during Spine Surgery in the Prone Position: A Prospective Randomized Trial.Medicina (Kaunas, Lithuania) · 2022Trial
- Article
- Timing of Great Saphenous Vein Assessment Influences Vein Caliber Before CABG.Journal of clinical medicine · 2026Article
- Study on the correlation between changes in perfusion index under different body positions and the risk of hypotension after anesthetic induction.BMC anesthesiology · 2026Observational
- Carbon Monoxide Poisoning: Diagnosis, Prognostic Factors, Treatment Strategies, and Future Perspectives.Diagnostics (Basel, Switzerland) · 2025Review
- Awake versus intubated video-assisted thoracoscopic surgery for pleural disease: a retrospective cohort study from a single tertiary center.Frontiers in surgery · 2025Article
- The Pleth Variability Index as a Guide to Fluid Therapy in Dogs Undergoing General Anesthesia: A Preliminary Study.Veterinary sciences · 2024Article
- Coronary Artery Occlusion with Sharp Blood Pressure Drop during General Anesthesia Induction: A Case Report.Medicina (Kaunas, Lithuania) · 2024Article
- A Comparison of Normalization Techniques for Individual Baseline-Free Estimation of Absolute Hypovolemic Status Using a Porcine Model.Biosensors · 2024Article
- Balanced anesthesia in pigeons (Frontiers in physiology · 2024Article
- Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone.Animals : an open access journal from MDPI · 2023Article
- Ketamine administration in idiopathic epileptic and healthy control dogs: Can we detect differences in brain metabolite response with spectroscopy?Frontiers in veterinary science · 2022Article
- Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis.Brazilian journal of veterinary medicine · 2022Article
- Mouse Anesthesia: The Art and Science.ILAR journal · 2021Review
- Levosimendan-induced venodilation is mediated by opening of potassium channels.ESC heart failure · 2021Review
- Recognizing blood pressure patterns in sedated critically ill patients on mechanical ventilation by spectral clustering.Annals of translational medicine · 2021Article
- Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia.Veterinary sciences · 2021Article
- Perioperative Morbidity and Complications in Patients With an Established Ileostomy Undergoing Major Abdominal Surgery: A Retrospective Study.Frontiers in surgery · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the utility and benefits of anesthesia and analgesia are irrefutable, their practice is not void of risks. Almost all drugs that produce anesthesia endanger cardiovascular stability by producing dose-dependent impairment of cardiac function, vascular reactivity, and compensatory autoregulatory responses. Whereas anesthesia-related depression of cardiac performance and arterial vasodilation are well recognized adverse effects contributing to anesthetic risk, far less emphasis has been placed on effects impacting venous physiology and venous return. The venous circulation, containing about 65-70% of the total blood volume, is a pivotal contributor to stroke volume and cardiac output. Vasodilation, particularly venodilation, is the primary cause of relative hypovolemia produced by anesthetic drugs and is often associated with increased venous compliance, decreased venous return, and reduced response to vasoactive substances. Depending on factors such as patient status and monitoring, a state of relative hypovolemia may remain clinically undetected, with impending consequences owing to impaired oxygen delivery and tissue perfusion. Concurrent processes related to comorbidities, hypothermia, inflammation, trauma, sepsis, or other causes of hemodynamic or metabolic compromise, may further exacerbate the condition. Despite scientific and technological advances, clinical monitoring and treatment of relative hypovolemia still pose relevant challenges to the anesthesiologist. This short perspective seeks to define relative hypovolemia, describe the venous system's role in supporting normal cardiovascular function, characterize effects of anesthetic drugs on venous physiology, and address current considerations and challenges for monitoring and treatment of relative hypovolemia, with focus on insights for future therapies.
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Registered trials
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