ArticleFrontiers in public health2018
Evidence of Increase in Mortality After the Introduction of Diphtheria-Tetanus-Pertussis Vaccine to Children Aged 6-35 Months in Guinea-Bissau: A Time for Reflection?
Article in Frontiers in public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Non-specific effects of Pneumococcal and Haemophilus vaccines in children aged 5 years and under: a systematic review.BMJ open · 2023Pooled it
- Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis.Dermatitis : contact, atopic, occupational, drugPooled it
- The origin of non-specific effects of vaccines and the role of randomised clinical trials.Human vaccines & immunotherapeutics · 2026Review
- Update on Selected Adverse Events of Concern Following Immunization With Acellular Pertussis Vaccines, a Narrative Review.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Economic and healthcare determinants of under-five mortality in low-income countries.BMC public health · 2025Article
- Do Pentavalent (DTwP-Hib-HBV) vaccines have sex-differential nonspecific effects? An observational study.Human vaccines & immunotherapeutics · 2023Observational
- A Novel Mathematical Model That Predicts the Protection Time of SARS-CoV-2 Antibodies.Viruses · 2023Article
- Trained immunity: A "new" weapon in the fight against infectious diseases.Frontiers in immunology · 2023Review
- Stopping Oral Polio Vaccine (OPV) After Defeating Poliomyelitis in Low- and Middle-Income Countries: Harmful Unintended Consequences? Review of the Nonspecific Effects of OPV.Open forum infectious diseases · 2022Article
- Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice.NPJ vaccines · 2022Article
- Deceptology in cancer and vaccine sciences: Seeds of immune destruction-mini electric shocks in mitochondria: Neuroplasticity-electrobiology of response profiles and increased induced diseases in four generations - A hypothesis.Clinical and translational medicine · 2020Review
- Do inequalities exist in the disadvantaged populations? Levels and trends of full and on-time vaccination coverage in two Nairobi urban informal settlements.Global epidemiology · 2020Article
- Adverse events following measles-mumps-rubella-varicella vaccine: an independent perspective on Italian pharmacovigilance data.F1000Research · 2020Article
- Article
- Out-of-sequence DTP and measles vaccinations and child mortality in Guinea-Bissau: a reanalysis.BMJ open · 2019Article
- Effects of sex and birth weight on non-specific health services use following whole-cell pertussis vaccination: a self-controlled case series analysis.Human vaccines & immunotherapeutics · 2019Article
- First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines.mSphere · 2018Review
- Revised World Health Organization (WHO)'s causality assessment of adverse events following immunization-a critique.F1000Research · 2018Article
- Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWhole-cell diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) were introduced to children in Guinea-Bissau in 1981. We previously reported that DTP in the target age group from 3 to 5 months of age was associated with higher overall mortality. DTP and OPV were also given to older children and in this study we tested the effect on mortality in children aged 6-35 months.
methodsIn the 1980s, the suburb Bandim in the capital of Guinea-Bissau was followed with demographic surveillance and tri-monthly weighing sessions for children under 3 years of age. From June 1981, routine vaccinations were offered at the weighing sessions. We calculated mortality hazard ratio (HR) for DTP-vaccinated and DTP-unvaccinated children aged 6-35 months using Cox proportional hazard models. Including this study, the introduction of DTP vaccine and child mortality has been studied in three studies; we made a meta-estimate of these studies.
resultsAt the first weighing session after the introduction of vaccines, 6-35-month-old children who received DTP vaccination had better weight-for-age
conclusionAlthough having better nutritional status and being protected against three infections, 6-35 months old DTP-vaccinated children tended to have higher mortality than DTP-unvaccinated children. All studies of the introduction of DTP have found increased overall mortality.
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