Evidence map›Paper›PMID 29616147›Full record

ArticleBMJ global health2018

Dynamics of paediatric urogenital schistosome infection, morbidity and treatment: a longitudinal study among preschool children in Zimbabwe.

Derick Nii Mensah Osakunor, Takafira Mduluza, Nicholas Midzi, Margo Chase-Topping, Masceline Jenipher Mutsaka-Makuvaza, Theresa Chimponda, Enwono Eyoh, Tariro Mduluza, Lorraine Tsitsi Pfavayi, Welcome Mkululi Wami and 5 more

Open access · goldAbstract read
In one paragraph

Article in BMJ global health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Parasite epidemiology and control · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Derick Nii Mensah OsakunorCentre for Infection, Immunity and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4853-5384
Takafira MduluzaDepartment of Biochemistry, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Nicholas MidziDepartment of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Margo Chase-ToppingCentre for Immunity, Infection and Evolution, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Masceline Jenipher Mutsaka-MakuvazaDepartment of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Theresa ChimpondaDepartment of Biochemistry, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Enwono EyohCentre for Infection, Immunity and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.
Tariro MduluzaDepartment of Biochemistry, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Lorraine Tsitsi PfavayiDepartment of Biochemistry, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Welcome Mkululi WamiCentre for Infection, Immunity and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.
Seth Appiah AmanfoCentre for Immunity, Infection and Evolution, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Janice MurrayCentre for Infection, Immunity and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.
Clement TshumaEpidemiology and Disease Control, Ministry of Health and Child Care, Harare, Zimbabwe.
Mark Edward John WoolhouseCentre for Immunity, Infection and Evolution, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Francisca MutapiCentre for Infection, Immunity and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.
Centre for Immunity, Infection and Evolution · GBUniversity of Zimbabwe · ZWMinistry of Health and Child Welfare · ZW

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundRecent research has shown that in schistosome-endemic areas preschool-aged children (PSAC), that is, ≤5 years, are at risk of infection. However, there exists a knowledge gap on the dynamics of infection and morbidity in this age group. In this study, we determined the incidence and dynamics of the first urogenital schistosome infections, morbidity and treatment in PSAC.

methodsChildren (6 months to 5 years) were recruited and followed up for 12 months. Baseline demographics, anthropometric and parasitology data were collected from 1502 children. Urinary morbidity was assessed by haematuria and growth-related morbidity was assessed using standard WHO anthropometric indices. Children negative for

resultsAt baseline, the prevalence of

conclusionWe demonstrated for the first time the incidence of schistosome infection in PSAC, along with microhaematuria, which appears within 3 months of first infection and resolves after praziquantel treatment. A proportion of stunting and malnutrition is attributable to

Indexed as

dynamicsincidencemorbiditypaediatricpraziquantel efficacypreschoolprevalenceschistosomiasisZimbabwe

Identifiers

PMID29616147
PMCPMC5875666
OpenAlexW2795176704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.