Evidence map›Paper›PMID 29616115›Full record

ArticleOncology letters2018

Expression of multiple immune checkpoint molecules on T cells in malignant ascites from epithelial ovarian carcinoma.

Yuichi Imai, Kosei Hasegawa, Hirokazu Matsushita, Nao Fujieda, Sho Sato, Etsuko Miyagi, Kazuhiro Kakimi, Keiichi Fujiwara

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Guideline
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  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Mesenchymal ovarian cancer cells promote CD8NPJ systems biology and applications · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Targeting of the tumor immune microenvironment by metformin.Journal of cell communication and signaling · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yuichi ImaiDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka-shi, Saitama 350-1298, Japan.
Kosei HasegawaDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka-shi, Saitama 350-1298, Japan.
Hirokazu MatsushitaDepartment of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo 113-8655, Japan.
Nao FujiedaDepartment of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo 113-8655, Japan.
Sho SatoDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka-shi, Saitama 350-1298, Japan.
Etsuko MiyagiDepartment of Obstetrics and Gynecology, Yokohama City University, Yokohama-shi, Kanagawa 236-0004, Japan.
Kazuhiro KakimiDepartment of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo 113-8655, Japan.
Keiichi FujiwaraDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka-shi, Saitama 350-1298, Japan.
Saitama Medical University · JPUniversity of Tokyo Hospital · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expression of immune checkpoint molecules, including programmed cell death protein-1 (PD-1), has been reported on T cells in various types of cancer. However, the expression status of these molecules in the tumor microenvironment of epithelial ovarian cancer (EOC) has not yet been studied. A total of 54 cases of malignant ascites from patients with EOC were analyzed in the present study. The expression of PD-1, lymphocyte-activation gene-3 (LAG-3), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) and B and T lymphocyte attenuator (BTLA) on cluster of differentiation (CD)4

Indexed as

ascitesB and T lymphocyte attenuatorlymphocyte-activation gene-3ovarian cancerprogrammed cell death protein-1T-cell immunoglobulin and mucin-domain containing-3

Identifiers

PMID29616115
PMCPMC5876465
OpenAlexW2792067978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.