ArticleFrontiers in plant science2018
Arabidopsis GAAP1 and GAAP3 Modulate the Unfolded Protein Response and the Onset of Cell Death in Response to ER Stress.
Article in Frontiers in plant science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- RING-type E3 ligase RhSAREL promotes flower senescence by differentially regulating two TMBIM family members, RhTMBIM1 and RhTMBIM7, in Rosa hybrida.Plant physiology · 2026Article
- Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant-Pathogen Interface.Plant biotechnology journal · 2026Review
- Bax inhibitor-1 confers resistance to Phytophthora parasitica and is antagonized by RTP1 in Arabidopsis.Stress biology · 2026Article
- Characterization of theInternational journal of molecular sciences · 2024Article
- Programmed cell death regulator BAP2 is required for IRE1-mediated unfolded protein response in Arabidopsis.Nature communications · 2024Article
- Role and mechanism of endoplasmic reticulum stress and NLRP3 inflammasome in acute kidney injury.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Endoplasmic Reticulum Stress and Unfolded Protein Response Signaling in Plants.International journal of molecular sciences · 2022Review
- How Lipids Contribute to Autophagosome Biogenesis, a Critical Process in Plant Responses to Stresses.Cells · 2021Review
- ER-Phagy and Its Role in ER Homeostasis in Plants.Plants (Basel, Switzerland) · 2020Review
- [Endoplasmic reticulum stress enhances tumor necrosis factor-Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases.Frontiers in cell and developmental biology · 2020Review
- Arabidopsis GAAPs interacting with MAPR3 modulate the IRE1-dependent pathway upon endoplasmic reticulum stress.Journal of experimental botany · 2019Article
- Article
- Misregulation of ER-Golgi Vesicle Transport Induces ER Stress and Affects Seed Vigor and Stress Response.Frontiers in plant science · 2018Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of human Golgi antiapoptotic proteins (GAAPs) resembles that of BAX inhibitor-1, with apoptosis inhibition triggered by intrinsic and extrinsic stimuli. However, little is known about the function of GAAP-related proteins in plants. Here, we studied Arabidopsis GAAP1 and GAAP3 and found that they were localized on the cellular membrane, including the endoplasmic reticulum (ER) membrane. The function of GAAP1/GAAP3 in ER-stress response was tested, and results showed that single or double mutation in GAAP1 and GAAP3 reduced plant survival and enhanced cell death under ER stress. The expression of both genes was induced by various abiotic stress signals. Quantitative real-time polymerase chain reaction analysis showed that GAAP1/GAAP3 level affected the expression pattern of the unfolded-protein response (UPR) signaling pathway genes upon prolonged ER stress. The mutation in both GAAP1 and GAAP3 genes promoted and enhanced UPR signaling when confronted with mild ER stress. Moreover, GAAP1/GAAP3 inhibited cell death caused by ER stress and promoted plant-growth recovery by turning down inositol-requiring enzyme 1 (IRE1) signaling after ER stress had been relieved. Co-immunoprecipitation (Co-Ip) and BiFC assays showed that GAAP1/GAAP3 interacted with IRE1. These data suggested that GAAP1/GAAP3 played dual roles in the negative regulation of IRE1 activity and anti-programmed cell death.
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