Evidence map›Paper›PMID 29616040›Full record

ArticleFrontiers in immunology2018

Cholinergic Activation Enhances Resistance to Oral

Ray M Al-Barazie, Ghada Hassan Bashir, Mohammed M Qureshi, Yassir A Mohamed, Ashraf Al-Sbiei, Saeed Tariq, Wim J Lammers, Basel K Al-Ramadi, Maria J Fernandez-Cabezudo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ray M Al-BarazieDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Ghada Hassan BashirDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Mohammed M QureshiDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Yassir A MohamedDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Ashraf Al-SbieiDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Saeed TariqDepartment of Anatomy, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Wim J LammersDepartment of Physiology, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Basel K Al-RamadiDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
Maria J Fernandez-CabezudoDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab University, Al-Ain, United Arab Emirates.
United Arab Emirates University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host. The extent of activation of the inflammatory response is tightly regulated through immunological and neural pathways. Previously, we demonstrated that cholinergic stimulation confers enhanced protection in experimental animals orally infected with virulent

Indexed as

AcetylcholinesteraseAdministration, OralAnimalsBacterial LoadCell DegranulationCells, CulturedCholinergic AgonistsCholinesterase InhibitorsCytokinesDisease Models, AnimalHumansIleumImmunity, InnateIntestinal MucosaMaleMiceAcetylcholinesteraseCholinergic AgonistsCholinesterase InhibitorsCytokinesParaoxonacetylcholineantimicrobial peptidescholinergic pathwaymucosal innate immunityPaneth cellsSalmonella infection

Identifiers

PMID29616040
PMCPMC5867304
OpenAlexW2792818189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.