Evidence map›Paper›PMID 29616022›Full record

ArticleFrontiers in immunology2018

Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling.

Jessica C Kling, Margaret A Jordan, Lauren A Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T K Nguyen, Deepak Mittal, Rehan Villani, Raymond J Steptoe and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Wnt/β-catenin signaling pathway in liver biology and tumorigenesis.In vitro cellular & developmental biology. Animal · 2024
    Review
  4. The role of Evi/Wntless in exporting Wnt proteins.Development (Cambridge, England) · 2023
    Review
  5. Article
  6. IFN-γ and TGF-β, Crucial Players in Immune Responses: A Tribute to Howard Young.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Review
  7. Article
  8. MyeloidFrontiers in endocrinology · 2022
    Article
  9. Article
  10. Wnt Signaling in the Tumor Microenvironment.Advances in experimental medicine and biology · 2021
    Article
  11. Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Jessica C KlingThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Margaret A JordanComparative Genomics Centre, James Cook University, Townsville, QLD, Australia.
Lauren A PittDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Jana MeinersThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Thao Thanh-TranThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Le Son TranThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Tam T K NguyenThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Deepak MittalThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Rehan VillaniThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Raymond J SteptoeThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Kiarash KhosrotehraniThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
Stuart P BerzinsDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Alan G BaxterComparative Genomics Centre, James Cook University, Townsville, QLD, Australia.
Dale I GodfreyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Antje BlumenthalThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
University of Queensland · AUTranslational Research Institute · AUJames Cook University · AUPeter Doherty Institute · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity. Interferon gamma (IFN-γ) and IL-4 are key cytokines rapidly produced by NKT cells upon recognition of glycolipid antigens presented by antigen-presenting cells (APCs). It has previously been reported that the transcriptional coactivator β-catenin regulates NKT cell differentiation and functionally biases NKT cell responses toward IL-4, at the expense of IFN-γ production. β-Catenin is not only a central effector of Wnt signaling but also contributes to other signaling networks. It is currently unknown whether Wnt ligands regulate NKT cell functions. We thus investigated how Wnt ligands and β-catenin activity shape liver NKT cell functions

Indexed as

AnimalsBenzothiazolesbeta CateninBridged Bicyclo Compounds, HeterocyclicFemaleInterferon-gammaInterleukin-4Intracellular Signaling Peptides and ProteinsMiceNatural Killer T-CellsPyrimidinonesReceptors, G-Protein-CoupledWnt Signaling PathwayBenzothiazolesbeta CateninBridged Bicyclo Compounds, HeterocyclicGpr177 protein, mouseICG 001IFNG protein, mouseInterferon-gammaInterleukin-4Intracellular Signaling Peptides and ProteinsIWP-2 compoundPyrimidinonesReceptors, G-Protein-CoupledIL-12IL-4interferon gammanatural killer T cellWntα-galactosylceramideβ-catenin

Identifiers

PMID29616022
PMCPMC5864864
OpenAlexW2794256929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.