Evidence map›Paper›PMID 29616020›Full record

Trial reportFrontiers in immunology2018

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161

Yean K Yong, Alireza Saeidi, Hong Y Tan, Mohamed Rosmawati, Philip F Enström, Rami Al Batran, V Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh and 8 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. The role of PD‑1/PD‑L1 axis in liver diseases.Clinical and experimental medicine · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 5 countries.

Yean K YongLaboratory Center, Xiamen University Malaysia, Sepang, Malaysia.
Alireza SaeidiDepartment of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Hong Y TanLaboratory Center, Xiamen University Malaysia, Sepang, Malaysia.
Mohamed RosmawatiDepartment of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Philip F EnströmDivision of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Rami Al BatranDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
V VasukiDepartment of Microbiology, The Government Thiruvarur Medical College and Hospital, Thiruvarur, India.
Indranil ChattopadhyayDivision of Molecular Cancer Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.
Amudhan MurugesanThe Government Theni Medical College and Hospital, Theni, India.
Ramachandran VigneshLaboratory-Based Department, Universiti Kuala Lumpur, Ipoh, Malaysia.
Adeeba KamarulzamanDepartment of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Jayakumar RajarajeswaranDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Abdul W AnsariDepartment of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Jamuna VadiveluDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
James E UssherDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Vijayakumar VeluDepartment of Microbiology and Immunology, Emory Vaccine Center, Atlanta, GA, United States.
Marie LarssonDivision of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Esaki M ShankarCenter of Excellence for Research in AIDS, University of Malaya, Kuala Lumpur, Malaysia.
University Malaya Medical Centre · MYCentral University of Tamil Nadu · INLinköping University · SEUniversity of Malaya · MYXiamen University Malaysia · MYEmory Healthcare · USGovernment Medical College and Hospital · INUniversity of Kuala Lumpur · MYUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells, defined as CD161

Indexed as

AdultCD8-Positive T-LymphocytesDNA, ViralFemaleGene Expression RegulationHepatitis B, ChronicHumansMaleMiddle AgedMucous MembraneNK Cell Lectin-Like Receptor Subfamily BProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell, alpha-betaDNA, ViralKLRB1 protein, humanNK Cell Lectin-Like Receptor Subfamily BPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell, alpha-betaCTLA-4HBV infectionHLA-DRimmune exhaustionimmunosenescencemucosal-associated invariant T cellsPD-1

Identifiers

PMID29616020
PMCPMC5868455
OpenAlexW2791467214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.