Evidence map›Paper›PMID 29615958›Full record

ArticleFrontiers in neurology2018

Lymphocytes Contribute to the Pathophysiology of Neonatal Brain Injury.

Arshed Nazmi, Anna-Maj Albertsson, Eridan Rocha-Ferreira, Xiaoli Zhang, Regina Vontell, Aura Zelco, Mary Rutherford, Changlian Zhu, Gisela Nilsson, Carina Mallard and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
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  9. Article
  10. Microglial iron trafficking: new player in brain injury.Turkish journal of medical sciences · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. The association ofFrontiers in neurology · 2022
    Article
  16. Article
  17. The role of lymphocytes in neonatal encephalopathy.Brain, behavior, & immunity - health · 2021
    Review
  18. Review
  19. Article
  20. Gut-derived T cells might cause brain injury in NEC.Nature reviews. Gastroenterology & hepatology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Arshed NazmiDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anna-Maj AlbertssonDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Eridan Rocha-FerreiraDepartment of Clinical Sciences, Sahlgrenska University Hospital, Gothenburg, Sweden.
Xiaoli ZhangDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Regina VontellDepartment of Perinatal Imaging and Health, Centre for the Developing Brain, King's College London, St. Thomas' Hospital, London, United Kingdom.
Aura ZelcoDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Mary RutherfordDepartment of Perinatal Imaging and Health, Centre for the Developing Brain, King's College London, St. Thomas' Hospital, London, United Kingdom.
Changlian ZhuDepartment of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gisela NilssonDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Carina MallardDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Henrik HagbergDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jacqueline C Y LaiDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jianmei W LeavenworthDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, United States.
Xiaoyang WangDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
University of Gothenburg · SEKing's College London · GBSahlgrenska University Hospital · SESt Thomas' Hospital · GBUniversity of Alabama at Birmingham · US

Funding

Medical Research Council MC_U120088465
6 · The paper itself

Abstract

backgroundPeriventricular leukomalacia (PVL) is the most common form of preterm brain injury affecting the cerebral white matter. This type of injury involves a multiphase process and is induced by many factors, including hypoxia-ischemia (HI) and infection. Previous studies have suggested that lymphocytes play a significant role in the pathogenesis of brain injury, and the aim of this study was to determine the contribution of lymphocyte subsets to preterm brain injury.

methodsImmunohistochemistry on brain sections from neonatal mice was performed to evaluate the extent of brain injury in wild-type and T cell and B cell-deficient neonatal mice (

resultsMature lymphocyte-deficient

conclusionLymphocytes were found in the injured brain after injury in both mice and humans, and lack of mature lymphocytes protected neonatal mice from HI-induced brain white matter injury. This finding provides insight into the pathology of perinatal brain injury and suggests new avenues for the development of therapeutic strategies.

Indexed as

brainbrain damagehypoxia–ischemialymphocytesmouse modelspreterm

Identifiers

PMID29615958
PMCPMC5868390
OpenAlexW2793918453

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.