Evidence map›Paper›PMID 29615849›Full record

ArticleFrontiers in neuroscience2018

Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria.

Francesca Nardecchia, Rosamaria Orlando, Luisa Iacovelli, Marco Colamartino, Elena Fiori, Vincenzo Leuzzi, Sonia Piccinin, Robert Nistico, Stefano Puglisi-Allegra, Luisa Di Menna and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Altered Expression andCurrent neuropharmacology · 2022
    Article
  7. Article
  8. Engineering Organoids forFrontiers in molecular neuroscience · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Francesca NardecchiaDepartment of Physiology and Pharmacology, Sapienza Università di Roma, Rome, Italy.
Rosamaria OrlandoDepartment of Physiology and Pharmacology, Sapienza Università di Roma, Rome, Italy.
Luisa IacovelliDepartment of Physiology and Pharmacology, Sapienza Università di Roma, Rome, Italy.
Marco ColamartinoDaniel Bovet Department of Psychology, Neurobiology Research Center, Sapienza Università di Roma, Rome, Italy.
Elena FioriDaniel Bovet Department of Psychology, Neurobiology Research Center, Sapienza Università di Roma, Rome, Italy.
Vincenzo LeuzziDepartment of Pediatrics and Child Neuropsychiatry, Sapienza Università di Roma, Rome, Italy.
Sonia PiccininDepartment of Physiology and Pharmacology, Sapienza Università di Roma, Rome, Italy.
Robert NisticoDepartment of Biology, Università degli Studi di Roma Tor Vergata, Rome, Italy.
Stefano Puglisi-AllegraDaniel Bovet Department of Psychology, Neurobiology Research Center, Sapienza Università di Roma, Rome, Italy.
Luisa Di MennaIRCCS Neuromed, Pozzilli, Italy.
Giuseppe BattagliaIRCCS Neuromed, Pozzilli, Italy.
Ferdinando NicolettiDepartment of Physiology and Pharmacology, Sapienza Università di Roma, Rome, Italy.
Tiziana PascucciDaniel Bovet Department of Psychology, Neurobiology Research Center, Sapienza Università di Roma, Rome, Italy.
Sapienza University of Rome · ITIstituto Neurologico Mediterraneo · ITUniversity of Rome Tor Vergata · ITFondazione Santa Lucia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied group-I metabotropic glutamate (mGlu) receptors in Pah

Indexed as

ENU2 micehippocampusintellectual disabilitymGluR5phenylketonuria

Identifiers

PMID29615849
PMCPMC5864888
OpenAlexW2791285144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.