Evidence map›Paper›PMID 29615812›Full record

ArticleScientific reports2018

Structure-function analysis and therapeutic efficacy of antibodies to fungal melanin for melanoma radioimmunotherapy.

J D Nosanchuk, A Jeyakumar, A Ray, E Revskaya, Z Jiang, R A Bryan, K J H Allen, R Jiao, M E Malo, B L Gómez and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Combining Targeted Radionuclide Therapy and Immune Checkpoint Inhibition for Cancer Treatment.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Review
  4. Targeting Melanin in Melanoma with Radionuclide Therapy.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

J D NosanchukAlbert Einstein College of Medicine, Bronx, New York, USA.
A JeyakumarAlbert Einstein College of Medicine, Bronx, New York, USA.
A RayAlbert Einstein College of Medicine, Bronx, New York, USA.
E RevskayaAlbert Einstein College of Medicine, Bronx, New York, USA.
Z JiangAlbert Einstein College of Medicine, Bronx, New York, USA.
R A BryanAlbert Einstein College of Medicine, Bronx, New York, USA.
K J H AllenUniversity of Saskatchewan, Saskatoon, SK, Canada.
R JiaoUniversity of Saskatchewan, Saskatoon, SK, Canada.
M E MaloUniversity of Saskatchewan, Saskatoon, SK, Canada.
B L GómezSchool of Medicine and Health Sciences, Universidad Rosario, Bogota, Colombia.
A MorgensternEuropean Commission, Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe, Germany.
F BruchertseiferEuropean Commission, Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe, Germany.
D RicklesRadImmune Therapeutics, Tarrytown, NY, USA.
G B ThorntonPain Therapeutics, Inc, Austin, TX, USA.
A BowenJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-1064-8372
A CasadevallJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
E DadachovaUniversity of Saskatchewan, Saskatoon, SK, Canada. ekaterina.dadachova@usask.ca.
Albert Einstein College of Medicine · USUniversity of Saskatchewan · CAJohns Hopkins University · USJoint Research Centre · DECassava Sciences (United States) · USDecImmune Therapeutics (United States) · USUniversidad del Rosario · CO

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Exploiting antibody catalysis for treating CryptococcosisR01AI162381 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2021 to 2025
$3.7M
NCI NIH HHS HHSN261201000017CNCI NIH HHS HHSN261201600017CNIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI162381NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

Metastatic melanoma remains difficult to treat despite recent approvals of several new drugs. Recently we reported encouraging results of Phase I clinical trial of radiolabeled with

Indexed as

Amino Acid SequenceAnimalsAntibodiesCell Line, TumorCutaneous Malignant MelanomaImmunoglobulin GImmunoglobulin MMelaninsMelanomaMiceRadioimmunotherapySkin NeoplasmsStructure-Activity RelationshipAntibodiesImmunoglobulin GImmunoglobulin MMelanins

Identifiers

PMID29615812
PMCPMC5882926
OpenAlexW2796465333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.