Evidence map›Paper›PMID 29615808›Full record

ArticleScientific reports2018

Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics.

Ida Rune, Bidda Rolin, Jens Lykkesfeldt, Dennis Sandris Nielsen, Łukasz Krych, Jenny E Kanter, Karin E Bornfeldt, Pernille Kihl, Karsten Buschard, Knud Josefsen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. The microbiome and rodent models of immune mediated diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2021
    Review
  6. Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models.International journal of molecular sciences · 2021
    Article
  7. A longitudinalCardiovascular diagnosis and therapy · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Ida RuneSection of Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Bidda RolinResearch Bioanalysis, Novo Nordisk A/S, Måløv, Denmark.
Jens LykkesfeldtSection of Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Dennis Sandris NielsenDepartment of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Łukasz KrychDepartment of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Jenny E KanterDepartment of Medicine, UW Medicine Diabetes Institute, University of Washington, Seattle, Washington, USA.
Karin E BornfeldtDepartment of Medicine, UW Medicine Diabetes Institute, University of Washington, Seattle, Washington, USA.
Pernille KihlSection of Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Karsten BuschardBartholin Institute, Rigshospitalet, København, Denmark.
Knud JosefsenBartholin Institute, Rigshospitalet, København, Denmark.
Johannes Josef FelsResearch Bioanalysis, Novo Nordisk A/S, Måløv, Denmark.
Alan MortensenSection of Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Berit ChristoffersenMetabolic Disease Research, Novo Nordisk A/S, Måløv, Denmark.
Rikke Kaae KirkMetabolic Disease Research, Novo Nordisk A/S, Måløv, Denmark.
Axel Kornerup HansenSection of Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. akh@sund.ku.dk.ORCID 0000-0003-1575-2507
University of Copenhagen · DKNovo Nordisk (Denmark) · DKRigshospitalet · DKUniversity of Washington · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2008 to 2019
$23.5M
HYPERGLYCEMIA, PROTEIN KINASES AND SMOOTH MUSCLE GROWTHR01HL062887 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 1998 to 2014
$4.7M
Obesity and Arterial MetabolismR01HL126028 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2015 to 2018
$1.7M
NHLBI NIH HHS P01 HL092969NHLBI NIH HHS R01 HL062887NHLBI NIH HHS R01 HL126028NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

In the apolipoprotein E-deficient mouse, the gut microbiota has an impact on the development of atherosclerosis, but whether such correlations are also present in rats requires investigation. Therefore, we studied female SD-Apoe

Indexed as

AnimalsAortaApolipoproteins EAtherosclerosisBody WeightDiet, High-FatDiet, WesternFemaleGastrointestinal MicrobiomeInsulin ResistanceLiverOxidative StressRatsTime FactorsApolipoproteins E

Identifiers

PMID29615808
PMCPMC5882891
OpenAlexW2805846806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.