Evidence map›Paper›PMID 29615792›Full record

Trial reportJournal of human hypertension2018

Exercise in patients with hypertension and chronic kidney disease: a randomized controlled trial.

Franklin C Barcellos, Fabricio Boscolo Del Vecchio, Annelise Reges, Gregore Mielke, Iná S Santos, Daniel Umpierre, Maristela Bohlke, Pedro C Hallal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of human hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01155128 (Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease), which is not on this map. Cited by 34 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 11 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01155128 phase4unknown statusnot on this map

Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease: a Randomized Clinical Trial

TypeinterventionalSponsorFederal University of PelotasRan2011 to 2012Enrolled200ConditionsCardiovascular Disease, Chronic Kidney Disease, Chronic Renal Disease, HypertensionArmsexercise aerobic
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 11 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  13. Effect of Long-term Exercise Training on Physical Performance and Cardiorespiratory Function in Adults With CKD: A Randomized Controlled Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Franklin C BarcellosPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil. fcbarcellos.sul@gmail.com.
Fabricio Boscolo Del VecchioSuperior School of Physical Education, Federal University of Pelotas, Pelotas, Brazil.
Annelise RegesSchool of Medicine, Catholic University of Pelotas, Pelotas, Brazil.
Gregore MielkePostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Iná S SantosPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Daniel UmpierreFederal University of Rio Grande do Sul, Porto Alegre, Brazil.
Maristela BohlkeSchool of Medicine, Catholic University of Pelotas, Pelotas, Brazil.ORCID 0000-0001-9372-3475
Pedro C HallalPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Universidade Católica de Pelotas · BRUniversidade Federal de Pelotas · BRThe University of Queensland · AUUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension and chronic kidney disease (CKD) are global public health problems, both associated with higher risk of cardiovascular (CV) and renal events. This trial randomized non-diabetic adult patients with hypertension and CKD stages 2-4 to 16 weeks of aerobic and resistance training or usual care. The primary outcome was the change in estimated glomerular filtration rate (eGFR). Secondary outcomes included changes in systolic and diastolic blood pressure (BP), body weight, fasting blood glucose, lipid profile, high-sensitivity C-reactive protein (hs-CRP), and functional capacity. The analysis was performed by intention-to-treat, using linear mixed-effects models for repeated measures over time. A hundred fifty patients were included in the intervention (76) or control (74) groups. No difference was found in eGFR, BP, body weight, or lipid profile changes between the groups. However, there were significant decreases in hs-CRP [-6.7(-11.7 to -1.8) mg/L] and fasting blood glucose [-11.3(-20.0 to -1.8) mg/dL], and an increase in functional capacity [2' Step Test 33.9 (17.7-50.0); 30″ Stand Test 2.3 (0.9-3.7)] in exercise group compared with control group. The results of this RCT show that combined aerobic and resistance training could reduce inflammation and insulin resistance in hypertensive patients with earlier stages of CKD, without a significant effect on kidney disease progression. Clinical trials.gov NCT01155128.

Indexed as

Glomerular Filtration RateResistance TrainingAgedBlood GlucoseC-Reactive ProteinFemaleHumansHypertensionMaleMiddle AgedPatient ComplianceRenal Insufficiency, ChronicRisk FactorsTreatment OutcomeBlood GlucoseC-Reactive Protein

Identifiers

PMID29615792
OpenAlexW2795743817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.